胸腺素β10的研究进展  

Advances in Thymosin β10

作　　者：和金周[1,2] 周长林[1] 方宏清[2] 

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009 [2]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2012年第4期613-616,共4页Letters in Biotechnology

基　　金：国家自然基金面上项目(30870049)

摘　　要：胸腺素β10(Tβ10)是胸腺素β家族成员。与Tβ4一样,Tβ10也是与细胞运动有关的肌动蛋白隐蔽蛋白。研究发现Tβ10可能与某些肿瘤行为,如细胞增殖、细胞凋亡、血管生成、肿瘤转移等相关。目前细胞中Tβ10作用的分子机制尚不明确。有研究表明,Tβ10有差别地表达于胚胎发生和神经发育过程中,在炎症及肿瘤发生时其表达量也有所上调,甚至过表达。我们简要综述了Tβ10的研究进展,包括差异表达、功能、机制,以及在肿瘤治疗、创伤愈合等疾病中的潜在应用。Thymosin β10（Tβ10） is a member of the β-thymosin family, which has biological activities as an aetin-sequestering protein involved in cell motility. Tβ10 may be correlated with tumor biology such as cell proliferation, apoptosis, angiogenesis, and metastasis behavior. However, the molecular mechanisms of action of Tβ10 in cancer are largely unknown. TIll0 is differentially expressed in embryogenesis and neuronal development. Its expression is also increased in many inflammatory conditions and tumorigenesis. In this review we briefly summarized recent advances in Tβ10 research including differential expression, functions, mechanisms, and therapeutic applications in cancer, wound healing, and other diseases.

关 键 词：胸腺素β10 肌动蛋白 差异表达 肿瘤治疗 创伤愈合 

分 类 号：Q574[生物学—生物化学]