帕瑞昔布钠对妇科经腹手术全凭静脉麻醉患者的影响  

Effects of parecoxib on postoperative pain during total intravenous anesthesia in patients undergoing transabdominal gynecologic operation

作　　者：秦红[1] 柴小青[1] 潘建辉[1] 

机构地区：[1]安徽医科大学附属省立医院麻醉科,合肥市230001

出　　处：《临床麻醉学杂志》2012年第7期687-688,共2页Journal of Clinical Anesthesiology

摘　　要：目的观察帕瑞昔布钠对妇科经腹手术行全凭静脉麻醉术后疼痛的影响。方法全麻下行妇科经腹手术患者60例,随机均分为两组。当血流动力学指标趋于平稳后及BIS值在40～60,分别静脉注射帕瑞昔布钠40mg(5ml)(P组)和生理盐水5ml(C组),记录给药前、给药后5、10、15、20、30、40min的HR、MAP、BIS。并记录拔管时间、清醒时间、不良反应及拔管后45minVAS疼痛评分。结果 P组VAS评分明显低于C组(P<0.05),两组给药前后BIS、HR、MAP和拔管时间、清醒时间及躁动发生率差异无统计学意义。结论静注帕瑞昔布钠40mg对妇科经腹手术行全凭静脉麻醉患者可显著缓解术后疼痛,对BIS值、术后拔管时间、清醒时间无明显影响。Objective To observe the effect of parecoxib on postoperative pain during total intravenous anesthesia in patients undergoing transabdominal gynecologic operation. Methods＇ Sixty patients undergoing transabdorninal gynecologic operation under general anesthesia were randomly divided into two groups, Group P received intravenous parecoxib 40 mg（5 ml）and group C received normal saline 5 ml when the hemodynamics and bispectral index 40-60 were stable HR, MAP, BIS were recorded before and 5, 10, 15, 20, 30, and 40 min after parecoxib or saline administration. The extubation time, recovery time, side effects, and ＇VAS score of pain at 45 rain after extubafion were recorded too. Results VAS scores of pain were markedly lower in group P than that of group C （P 〈0. 05）. There were no significant difference in hemodynamics index, the extubation time, consciousness recovery time and incidence of agitation between the two groups. Condusion Forty rng parecoxib intravenously does not change BIS during total intravenous anesthesia and postoperative conscious recover in patients undergoing transabdominal gynecologic operation, but with a better analgesic effect.

关 键 词：帕瑞昔布钠 全凭静脉麻醉 脑电双频指数 术后疼痛 

分 类 号：R614[医药卫生—麻醉学]