地佐辛、舒芬太尼在开腹全子宫切除术后静脉自控镇痛效果的对比研究  

Comparison of the analgesic effect of dezocine and sufentanil for patient-controlled analgesia followed by hysterectomy

作　　者：肖莉[1] 赵斌江[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院麻醉科,100038

出　　处：《北京医学》2012年第8期686-688,共3页Beijing Medical Journal

摘　　要：目的比较地佐辛与舒芬太尼自控静脉镇痛(PCIA)的效果和不良反应。方法 60例全子宫切除术患者,年龄36～70岁,ASAⅠ～Ⅱ级,随机分为两组。术后A组PCIA采用地佐辛40mg+昂丹司琼8.0mg,稀释于100ml生理盐水中;B组PCIA采用舒芬太尼100μg+昂丹司琼8.0mg,稀释于100ml生理盐水中,于术后6、12、24、48h采用视觉模拟评分法(VAS)评定镇痛效果及不良反应。结果两组患者术后48h内VAS评分差异均无统计学意义。两组患者术后恶心(10.0%vs.13.3%)、呕吐(3.3%vs.6.7%)、皮肤瘙痒(0vs.6.7%)的发生率及排气时间[(23.6±2.5)hvs.(19.9±3.2)h]差异均无统计学意义。结论地佐辛PCIA镇痛效果确切,安全可靠。Objective To compare the analgesic effects and adverse reactions of dezocine and sufentanil for pa- tient-controlled intravenous analgesia （PCIA） in hysterectomy. Methods Sixty patients without critical organ dysfunction, aged from 36-70 ys, ASA Ⅰ～Ⅱ grade, were randomized into two groups （n=30）. Each patient was given PCIA followed by operation. The PCIA regimen was dezocine 40 mg combined with ondansetron 8.0 mg in N.S 100 ml for Group A and sufentanil 100 p,g combined with ondansetron 8.0 mg in N.S 100 ml for Group B. The visual analogue scales （VAS） was adopted to assess pain intensity and side effects and the assessments were recorded at 6, 12, 24, 48 h after operation. Re- suits There was no significant difference in analgesic effect and adverse reactions between the Group A and B. Conclu- sion The analgesic effect of dezocine-based PCIA is available and reliable for postoperative pain management followed by hysterectomy.

关 键 词：子宫切除术 地佐辛 舒芬太尼 急性术后镇痛 

分 类 号：R614[医药卫生—麻醉学]