扶正解毒煎剂和环磷酰胺对小鼠腹腔巨噬细胞产生肿瘤坏死因子的影响  

Effects of Fu-Zheng Jie-Du Decoction(扶正解毒煎剂)and Cyclophosphamidum on the Production of Tumor Necrosis Factor in Mice

作　　者：魏育林[1] 赵天德[1] 赵天豫[1] 张代钊[1] 于锐锋 金恩源[1] 

机构地区：[1]中日友好医院,北京100029

出　　处：《中西医结合杂志》1990年第6期353-355,共3页

摘　　要：扶正解毒煎剂为抗肿瘤治疗的辅助性中药制剂。本实验从体内和体外两方面研究扶正解毒煎剂和环磷酰胺对正常及荷瘤小鼠腹腔巨噬细胞产生肿瘤坏死因子的影响。结果表明:在体外,大肠杆菌脂多糖有诱生肿瘤坏死因子的作用。相反,扶正解毒煎剂和环磷酰胺不但无诱生肿瘤坏死因子的作用,而且抑制脂多糖的诱生。在体内,环磷酰胺对荷瘤小鼠腹腔巨噬细胞产生肿瘤坏死因子的功能无明显影响。而扶正解毒煎剂则有明显增强经环磷酰胺治疗的荷瘤小鼠腹腔巨噬细胞产生肿瘤坏死因子的功能。Fu-Zheng Jie-Du decoction (FZJD) was an adjuvant drug of anti-tumor.In the present paper,the authors studied the effects of FZJD and cyclophosphamidum (CTX) on tumor necrosis factor (TNF) production of peritoneal macrophages (PM) of normal and EMT6 solid tumor-bearing mice.The results showed that in vitro,lipopolysaccharide (LPS) could induce TNF production of PM of normal mice;in contrast,FZJD and CTX were unable to induce TNF and inhibited the LPS effect.In vivo, CTX could not influence the TNF production of PM of tumor-bearing mice but FZJD could enhance the TNF production of PM of tumor-bearing mice treated with CTX.

关 键 词：扶正解毒煎剂 环磷酰胺 

分 类 号：R979.1[医药卫生—药品]