肝素类寡糖合成研究进展  

Recent Advances in the Synthesis of Heparan Sulfate Oligosaccharides

作　　者：尹晓娟[1,2] 闫俊[1,2] 姬胜利[1,2] 王凤山[1,2] 曹鸿志[1] 

机构地区：[1]山东大学国家糖工程技术研究中心,济南250012 [2]山东大学药学院,济南250012

出　　处：《有机化学》2012年第8期1388-1400,共13页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20902087;21172135);国家重点基础研究发展规划(973计划;No.2012CB822102)资助项目~~

摘　　要：肝素(heparin,HP)和硫酸乙酰肝素(heparan sulfate,HS)是糖胺聚糖(glycosaminoglycans,GAGs)家族中的一类线性硫酸化多糖,其结构复杂、生物活性多样.为了深入研究其结构序列与不同生物活性之间的关系,近年来针对肝素类寡糖的合成与功能研究成为糖化学和糖生物学研究的一个热点领域,涌现出一些新的合成方法与合成策略.选取了2001年以来国际上一些在肝素类寡糖的化学合成和酶法合成方面的代表性工作予以综述.Heparin（HP） and heparan sulfate（HS）,a member of the glycosaminoglycan（GAG） family,are structurally related linear polyanionic polysaccharides.These complex sulfated polysaccharides can interact with hundreds of proteins and play essential roles in mediating or modulating a variety of physiological and pathological processes.Accumulated evidence has shown that the biological functions of HP and HS can be critically dependent upon their precise structure sequences.To decipher the sequence code of HS and HP,many research groups have focus on the development of novel strategies and synthetic methods for the assembling of heparin oligosaccharides during the last decade.The key developments since 2001 in the chemical or chemoenzymatic synthesis of heparin oligosaccharides are covered in this review.

关 键 词：肝素 硫酸乙酰肝素 化学糖苷化 糖基转移酶 

分 类 号：O629[理学—有机化学]