一种合成β-甲酰氟硼吡咯新方法  

A New Approach to the Synthesis of β-Formyl-boron-dipyrromethenes

作　　者：叶家海[1] 叶文芳[1] 肖承涛[1] 陈雨[1] 王光普[1] 张文超[1] 

机构地区：[1]南京理工大学化工学院,南京210094

出　　处：《有机化学》2012年第8期1503-1508,共6页Chinese Journal of Organic Chemistry

摘　　要：氟硼吡咯和氮杂氟硼吡咯分别与草酰氯在N,N-二甲基甲酰胺溶液中发生Vilsmeier-Haack反应,生成相应的β-甲酰氟硼吡咯和β-甲酰氮杂氟硼吡咯.该反应分别在室温和50℃搅拌条件下顺利实现,并对氟硼吡咯和氮杂氟硼吡咯两种底物都具有较高产率.此外,该反应具有原料易得、低污染的优点.A series of β-formyl-boron-dipyrromethenes（BODIPYs） 2 and β-formyl-aza-BODIPYs 4 were synthesized from tetramethyl-BODIPYs 1 and tetraaryl-aza-BODIPYs 3 respectively via the Vilsmeier-Haack reaction using（COCl）2and DMF as the precursors efficiently.The Vilsmeier-Haack reaction was carried out smoothly under room temperature or 50 ℃ for BODIPYs or aza-BODIPYs respectively to give the β-formyl products in good yield.The advantage of this new method is the using of commercially available chemical and the less pollution.

关 键 词：氟硼吡咯 氮杂氟硼吡咯 β-甲酰化 Vilsmeier-Haack反应 

分 类 号：O627.8[理学—有机化学]