Fe(Ⅲ)催化的烯丙醇的Friedel-Crafts环化反应合成多取代茚  

Synthesis of Multisubstituted Indenes by Fe(Ⅲ)-Catalyzed Friedel-Crafts Cyclization of Allylic Alcohols

作　　者：张继坦[1] 张金花[1] 方旷[1] 束官莹[1] 谢美华[1] 

机构地区：[1]安徽师范大学化学与材料科学学院,芜湖241000

出　　处：《有机化学》2012年第8期1533-1538,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20772001)资助项目~~

摘　　要：在FeCl3 6H2O催化下,多取代的烯丙醇可以顺利进行分子内Friedel-Crafts环化反应,以中等到优良的产率得到一系列多取代茚化合物,该反应操作简单、反应条件温和.产物结构经IR,1H NMR,13C NMR,HR MS及X射线单晶衍射分析确证.FeCl3 6H2O-catalyzed intramolecular Friedel-Crafts cyclization of multisubstituted allylic alcohols proceeded smoothly and a series of multisubstituted indenes were synthesized in moderate to high yields.The reaction has the advantages of simple manipulation and mild reaction conditions.The products were characterized by IR,1H NMR,13C NMR,HR MS and X-ray diffraction analysis.

关 键 词：烯丙醇 FeCl36H2O Friedel-Crafts环化反应 茚 

分 类 号：O625.159[理学—有机化学]