萘基薁并[2,1-d]嘧啶-4-胺类衍生物的合成  

Synthesis of Naphthylazuleno[2,1-d]pyrimidin-4-amines

作　　者：王道林[1] 于家懿[1] 李伟[1] 崔庆涛[1] 冯姗姗[1] 

机构地区：[1]渤海大学化学化工与食品安全学院、辽宁省功能化合物合成与应用重点实验室,锦州121003

出　　处：《有机化学》2012年第8期1547-1551,共5页Chinese Journal of Organic Chemistry

基　　金：辽宁省科技厅(No.2011220022)资助项目~~

摘　　要：研究了萘基薁并[2,1-d]嘧啶-4-胺类衍生物的合成方法.以托酚酮、萘乙酸乙酯、N,N-二甲基甲酰胺二甲缩醛(DMF-DMA)及芳香胺为原料,依次经过氯代、缩合、环加成、环化反应得到目标产物.该反应操作简单、条件温和、收率良好.产物的结构经1H NMR,IR及元素分析等得以证实.In this paper,a synthetic method for naphthylazuleno[2,1-d]pyrimidin-4-amines was reported,which began from cheap tropolone,ethyl naphthaleneacetate,malononitrile N,N-dimethylformamide dimethyl acetal（DMF-DMA） and anilines,followed by chlorination,condensation,cyclization and then Dimroth rearrangement reaction,to give naphthylazuleno[2,1-d]pyrimidin-4-amines in moderate yields.The structures of synthesized compounds were determined by 1H NMR,IR spectra and elemental analysis.This method provides several advantages such as good yield and simple work-up procedure.

关 键 词：薁 薁并[2 1-d]嘧啶 萘乙酸乙酯 N N-二甲基甲酰胺二甲缩醛(DMF-DMA) 芳香胺 合成 

分 类 号：TQ254.1[化学工程—有机化工]