扩冠冲剂对心绞痛患者血浆锌与铜和红细胞谷胱甘肽过氧化物酶活性的影响  

Effects of Kuo-Guan Granule(扩冠冲剂)on Plasma Zinc,Copper and Erythrocyte GSH-Px in Patients with Angina Pectoris

作　　者：李应东[1] 车建途[1] 包福助[1] 赵梦华[1] 周葆初[2] 冯桂英[2] 

机构地区：[1]黑龙江中医学院附属医院 [2]哈尔滨医科大学克山病研究所

出　　处：《中西医结合杂志》1990年第6期348-350,325,共3页

摘　　要：本研究观察了31例冠心病心绞痛患者服中药扩冠冲剂1个月前后血浆 Zn、Cu 含量和红细胞谷胱甘肽过氧化物酶(GSH-Px)活性的变化。结果表明,治疗前患者血浆Zn 含量和红细胞 GSH-Px 活性低于正常对照组,血浆 Cu 含量高于正常对照组(P<0.01),服扩冠冲剂一个月后患者血浆 Zn、Cn 含量和红细胞 GSH-Px 活性与对照组比较无显著性差异(P>0.05)。提示中药扩冠冲剂对冠心病心绞痛患者的治疗作用可能与其调节体内微量元素的素乱有关。The changes of the plasma zinc,copper and erythrocyte glutathione peroxidase (GSH-Px) were measured by atomic absorption spectrometry and DTNB color development,in 31 patients suffering from coronary heart disease with angina Pectoris before and after taking Kuo-Guan granule one month.The results showed the plasma zinc was 16.83±2.60 μmol/L,copper 14.17±2.99 μmol/L,and erythrocyte GSH-Px 0.75±0.12 Eu/Hbmg/min in the normal control group.In patients with angina Pectoris,the plasma zinc was 14.39±4.44 μmol/L,copper 17.47±4.42 μmol/L,and erythrocyte GSH-Px 0.49±0.075 Eu/Hbmg/min before treatment;the plasma zinc was 20.17±3.97 μmol/L, Copper 15.74±3.15 μmol/L,and erythrocyte GSH-Px 0.72±0.10 Eu/Hbmg/min after treatment. These results indicate that the plasma zinc and erythrocyte GSH-Px were lower and copper was higher in the patients than the normal control group before treatment (P<0.01),the plasma zinc and erythrocyte GSH-Px were increased and copper was decreased after treatment (P<0.01).These suggest that therapeutic mechanism of Kuo-Guan granule to coronary heart disease with angina Pectoris may be related to it's regulation on trace elements disturbance in body.

关 键 词：冠心病 血锌 血铜 GSH-PX 

分 类 号：R541.405[医药卫生—心血管疾病]