2型糖尿病合并牙周病患者脂联素水平与颈动脉内膜-中膜厚度的关系  

Relationship between serum adiponection level and the intima-media thickness in type 2 diabetes mellitus with periodontitis

作　　者：陈辉[1] 于健[2] 周燕[2] 秦明群[3] 祖颖[4] 林爱萍[4] 石青峰[5] 

机构地区：[1]桂林医学院附属医院B超室,广西桂林541001 [2]桂林医学院附属医院内分泌科 [3]桂林医学院附属医院口腔科 [4]桂林医学院 [5]桂林医学院附属医院检验科

出　　处：《现代预防医学》2012年第16期4285-4286,4293,共3页Modern Preventive Medicine

基　　金：广西壮族自治区教育厅资助项目(200710MS178);桂林市科学研究与技术开发计划课题(20090545);广西科学基金项目(桂科自0832272)

摘　　要：目的探讨2型糖尿病合并牙周病脂联素的变化及与颈动脉内膜-中膜厚度的关系。方法 60例2型糖尿病合并牙周病患者(T2DM+牙周病),50例无牙周病的糖尿病患者(T2DM),测定两组人群空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂联素水平,并测量颈动脉内膜-中膜厚度(IMT)。同时计算体重指数(BMI)、胰岛素抵抗指数(HOMA-IR),分析2型糖尿病合并牙周病IMT与FPG、FINS、血脂、脂联素的关系。结果 2型糖尿病合并牙周病患者FPG、FINS、TG、IMT、HOMA-IR水平高于无牙周病的糖尿病患者,而HDL-C、脂联素水平低于无牙周病的糖尿病组,差异有统计学意义(P﹤0.05或P﹤0.01)。且IMT与年龄、糖尿病病程、FPG、TC、TG、LDL-C、FINS、HOMA-IR、BMI呈正相关(P﹤0.05或P﹤0.01),与HDL-C、脂联素呈负相关(P﹤0.01)。结论 2型糖尿病合并牙周病患者血清脂联素水平低于无牙周病的糖尿病组,且低脂联素水平与2型糖尿病合并牙周病患者IMT密切相关。OBJECTIVE To investigate the relationship of serum adiponection level with the intima-media thickness （IMT） in type 2 diabetes mellitus with periodontitis. METHODS The serum samples were taken from 60 cases with T2DM and periodonti- tis, 50 cases with T2DM, fasting plasma glucose （FPG）, fasting insulin （FINS）, total cholesterol （TC）, tr/glyceride （TG）, high density lipeprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） and Adiponectin were measured. The intima-media thickness （IMT） was detected. Body mass index （BMI） and homeostasis model assessment of insulin resis- tance （HOMA-IR） were calculated. RESULTS The patients with type 2 diabetes meUitus and periodontitis had significantly higher levels of FPG, FINS, TG, IMT, and HOMA-IR than type 2 diabetes mellitus. The levels of HDL-C and adiponectin were significantly lower in The patients with type 2 diabetes mellitus and periodontitis. CONCLUSION The level of Adiponectin in type 2 diabetes mellitus with periodontitis were significantly lower than those type 2 diabetes mellitus. Adiponectin may be in- timately related to the intima-media thickness.

关 键 词：2型糖尿病 牙周病 颈动脉内膜-中膜厚度 脂联素 

分 类 号：R587.1[医药卫生—内分泌]