支气管肺发育不良分子遗传学研究进展  

Study Advances in Molecular Genetics of Bronchopulmonary Dysplasia

作　　者：陈冲[1,2] 封志纯[1] 

机构地区：[1]北京军区总医院附属八一儿童医院儿科,北京100700 [2]中国人民解放军第二军医大学,上海200433

出　　处：《实用儿科临床杂志》2012年第16期1282-1284,共3页Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金(30973210)

摘　　要：支气管肺发育不良(BPD)的发病率在我国呈逐年上升趋势,但其病因及发病机制尚不十分清楚,研究表明,BPD的发生不仅与早产及氧体积分数等外源性因素有关,且有较大的遗传易感性。现就肺表面活性物质、基质金属蛋白酶、血管内皮生长因子、TNF、转化生长因子-β和结缔组织生长因子等在BPD发生发展中的调节作用的研究进展进行综述。The incidence of bronchopulmonary dysplasia （BPD） is tending to increase year after year in China. However, the etiology and pathogenesis have been unclear. BPD is not only related to external factors, such as preterm and oxygen, but also related to internal fac- tors, such as genetic susceptibility. This paper briefly reviews the regulative roles of pulmonary surfaetant, matrix metalloproteinase, vascular endothelial growth factor,tumour necrosis factor, transforming growth factor -β and connective tissue growth factor for BPD.

关 键 词：支气管肺发育不良 遗传易感性 发病机制 

分 类 号：R722.6[医药卫生—儿科]