吸入糖皮质激素联合茶碱或孟鲁司特治疗哮喘的对照研究  

Comparative study of inhaled corticosteroid combined with theophylline or with montelukast in treatment of asthma

作　　者：李英[1] 丁娟娟[1] 

机构地区：[1]河南省人民医院呼吸科,郑州450003

出　　处：《中国实用医刊》2012年第17期23-24,共2页Chinese Journal of Practical Medicine

摘　　要：目的比较吸入糖皮质激素（ICS）联合茶碱与ICS联合孟鲁司特治疗哮喘的疗效。方法80例中重度哮喘患者随机分为布地奈德联合缓释茶碱组（S组）及布地奈德联合孟鲁司特组（L组），比较两组患者治疗前后呼气峰流速（PEF）以及应用沙丁胺醇的次数。结果两组患者达到良好控制者比较差异无统计学意义（P〉0．05），治疗后两组PEF较治疗前显著降低（P〈0．05），但上述两指标改善率两组间比较差异无统计学意义（P〉0．05）。结论与ICS联合孟鲁司特比较，ICS联合茶碱治疗哮喘疗效相同且费用低廉。Objective To compare the efficacy of inhaled corticosteroid （ICS） combined with theophylline or with montelukast on asthma. Methods Eighty patients with asthma were randomly divid- ed into ICS combined with theophylline group（group S） and ICS combined with montelukast group （group L）. The peak expiratory flow rate（PEF） and the times of used salbutamol were measured between the two groups. Results Between the two groups, the PEF and the clinical reaction has no significant difference （ P 〈 0.05 ）. Conclusions ICS combined with theophylline or with montelukast in the treatment of asthma have the same effects, but the cost of ICS combined with theophylline is lower than that of ICS combined with montelukast.

关 键 词：哮喘 吸入激素 缓释茶碱 孟鲁司特 

分 类 号：R5[医药卫生—内科学]