己烯雌酚对生殖系统的影响及机制的研究进展  

Progress in effect of diethylstilbestrol on reproductive system and its mechanism

作　　者：杜娟[1] 潘红艳[1] 宫智勇[1] 

机构地区：[1]武汉工业学院食品科学与工程学院,湖北武汉430023

出　　处：《中国药理学与毒理学杂志》2012年第4期588-590,共3页Chinese Journal of Pharmacology and Toxicology

基　　金：国家"十一五"科技支撑计划项目(2009BADB9B02)~~

摘　　要：环境雌激素是影响人类和动物健康的重要因素。己烯雌酚是酚类环境的一种雌激素,对雌性和雄性动物的生殖系统有影响。己烯雌酚可能通过雌激素受体、下丘脑-垂体-性腺轴、氧化机制和基因水平变化等对生殖系统产生影响,本文综述了己烯雌酚对生殖系统的影响及机制。The environmental endocrine-disrupting chemicals have great effect on human and animal development and life. Diethylstilbestrol （DES） is an estrogenic endocrine disruptor with long-term health effects, possibly including depression following exposure in utero. DES may play a role through estrogen receptors, the hypothalamus-pituitary-gonadal axis, and oxidative damage. In this review, the effect on male and female reproductive organs and the mechanism of reproductive toxicity by DES are summarized.

关 键 词：己烯雌酚 生殖毒性 下丘脑-垂体-性腺轴 氧化性损伤 

分 类 号：R96[医药卫生—药理学]