妊娠母体血清hPL、uE3水平与子痫前期的关系  

Relationship between serum levels of unconjugated estriol and human placental lactogen in gravida and preeclampsia

作　　者：卢帅军[1,2] 厉倩[2] 朱长玲 陈锟[2] 谭龙益[2] 

机构地区：[1]南昌大学研究生院医学部,330006 [2]上海市第一人民医院宝山分院检验科,200940 [3]浙江省温州市中山医院妇产科,325027

出　　处：《国际检验医学杂志》2012年第13期1574-1575,共2页International Journal of Laboratory Medicine

基　　金：上海市科委生物医药引导基金资助项目(114119b0200)

摘　　要：目的分析妊娠母体血清人胎盘生乳素(hPL)和游离雌三醇(uE3)水平对子痫前期的预测价值。方法采用放射免疫(RIA)法检测80例子痫前期孕妇和80例健康孕妇28孕周时母体血清hPL、uE3水平。结果子痫前期组孕妇血清hPL、uE3水平分别为(6.20±1.34)μg/mL、(81.35±27.09)ng/mL,健康孕妇组hPL、uE3水平分别为(8.96±1.57)μg/mL、(89.77±35.50)ng/mL。相比健康孕妇组,子痫前期组hPL水平显著降低(P<0.05),血清uE3水平差异无统计学意义(P>0.05)。血清hPL和uE3水平的ROC曲线下面积分别为0.90(95%可信区间:0.83～0.97)、0.55(95%可信区间:0.42～0.68)。结论孕中期妊娠母体血清hPL的水平可作为子痫前期临床预测指标。Objective To analyze the value of maternal serum unconjugated estriol（uE3） and human placental lactogen（hPL） level for the prediction of preeclampsia.Methods The uE3 and hPL concentration in maternal serum at the 28th pregnant week in 80 preeclampsia patients and 80 healthy pregnant women were measured by radioimmunoassay（RIA）.Results Serum level of hPL in preeclampsia group was（6.20±1.34）μg/mL,significantly lower than（8.96±1.57）μg/mL in control group（P〈0.05）.Whereas,serum level of uE3 in preeclampsia group[（81.35±27.09）ng/mL] was not statistically different from（89.77±35.50）ng/mL in control group（P〉0.05）.Area under ROC curves for hPL and uE3 were 0.90（95%CI：0.83-0.97）and 0.55（95%CI：0.42-0.68）respectively.Conclusion Gestational maternal serum level of hPL in the second trimester could be used as a clinical predict marker for preeclampsia.

关 键 词：游离雌三醇 人胎盘生乳素 先兆子痫 ROC曲线 

分 类 号：R714.245[医药卫生—妇产科学]