不同肥胖指标与颅内动脉狭窄的相关性研究  

Correlation of Different Obesity Indexes and lntracranial Arterial Stenosis

作　　者：王安心[1] 周永[2] 赵性泉[2] 吴寿岭[3] 罗艳侠[1] 刘小雪[3] 陈朔华[3] 郭秀花[1] 

机构地区：[1]北京首都医科大学公共卫生与家庭医学学院,100069 [2]首都医科大学附属北京天坛医院神经内科 [3]河北联合大学附属开滦医院心内科

出　　处：《中国卒中杂志》2012年第8期631-635,共5页Chinese Journal of Stroke

摘　　要：目的研究不同肥胖指标[体重指数(body mass index,BMI)、腰围(waist circumference,WC)、腰围身高比(waist-to-height ratio,WHtR)、腰臀比(waist-to-hip ratio,WHpR)]与颅内动脉狭窄的关系。方法本研究采用横断面研究方法,以参加2006年7月至2007年10月健康查体的101 510例开滦集团在职及离退休职工,年龄大于40岁人群作为抽样框,对符合纳入与排除标准的5440例,研究者完成了临床资料的采集,包括:人口学信息、临床资料,并完成经颅多普勒超声检查。用单因素与多因素Logistic回归分析不同肥胖指标与颅内动脉狭窄的关系。结果研究对象共有5440例,平均年龄(55.1 7±11.78)岁,其中男性3257(59.87%),女性2183(40.13%)。检出颅内动脉狭窄患者716例,颅内动脉狭窄患病率为13.16%;单因素与多因素分析显示:不同肥胖指标均与颅内动脉狭窄具有一定的相关性,WHpR第二、三、四分位数与第一分位数之间的差异有显著性(P<0.05),调整后的比值比(odds ratio,OR)及95%可信区间(confidence interval,C1)分别为1.33(1.04～1.70)、1.34(1.05～1.73)、1.38(1.08-1.76)。结论人群中颅内动脉狭窄的患病率为13.16%;肥胖是颅内动脉狭窄的重要危险因素,不同肥胖指标中,WHpR具有更好的代表性。Objective To explore the relationship between different obesity indexes（body mass index[BMI], waist circumference[WC], waist-to-height ratio[WHtR], waist-to-hip ratio[WHpR]） and intracranial arterial stenosis. Methods The cross-sectional method was used and 5440 subjects were selected from 101 510 employees including retired ones aging over 40-years old who took part in health examination from July to October 2006 based on Kailuan Group Company. The clinical data collected consist of demography information, clinical baseline data and transcranial doppler（TCD） data. The relation between different obesity indexes and intracranial arterial stenosis was obtained using univariate and multivariate logistic regression analysis. Results The average age of the subjects is 55.17±11.78 years, Among 5440 subjects, the number of male subjects is 3257（59.87%） and female is 2183（40.13%）. Intracranial arterial stenosis is found in 716 subjects and the incidence is 13.16%. The univariate and multivariate logistic regression analysis shows that different obesity indexes correlate with intracranial arterial stenosis to a certain degree. The comparison between the second, third, forth quartile and the first quartile of WHpR are statistically significant（P〈0.05）. The adjusted odds ratio and 95% confidence interval are 1.33（1.04-1.70）, 1.34（1.05-1.73） and 1.38（1.08-1.76） respectively. Conclusion The prevalence of intracranial arterial stenosis is 13.16%; obesity is an important risk factor for intracranial arterial stenosis, and WHpR is a better representative index compared with other obesity indexes.

关 键 词：颅内动脉狭窄 肥胖 横断面研究 

分 类 号：R589.2[医药卫生—内分泌] R743.3[医药卫生—内科学]