结核蛋白芯片联合胸水ADA检测对结核性胸膜炎的诊断价值  被引量:1

Clinical value of tuberculosis protein chip combined with ADA levels of pleural effusion in diagnosis of tuberculos pleuritis

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作  者:杨冬梅[1] 陈小菊[1] 刘小燕[1] 陈绍平[1] 

机构地区:[1]川北医学院附属医院呼吸内科,四川南充637000

出  处:《川北医学院学报》2012年第4期360-362,共3页Journal of North Sichuan Medical College

基  金:四川省卫生厅科研项目(070293)

摘  要:目的:探讨结核蛋白芯片联合胸水腺苷脱氨酶(adenosine deaminase,ADA)检测对结核性胸膜炎的诊断价值。方法:对42例结核性胸腔积液患者和36例恶性胸腔积液患者血清标本进行结核蛋白芯片检测,同时检测胸水ADA。结果:42例结核性胸腔积液患者,结核蛋白芯片检测的灵敏度为69.05%,特异度为91.67%;而胸水ADA的灵敏度为83.33%,特异度为88.89%。两者联合检测的灵敏度为95.24%,高于单一结核蛋白芯片(69.05%)或胸水ADA(83.33%),差异有统计学意义(P<0.05)。两者联合检测的特异度为83.33%,低于单一结核蛋白芯片(91.67%)或胸水ADA(88.89%),差异无统计学意义(P>0.05)。结论:结核蛋白芯片联合胸水ADA检测可提高结核性胸膜炎的灵敏度,可作为结核性胸腔积液辅助诊断的有效方法。Objective :To explore the clinical value of tuberculosis protein chip combined with adenosine deaminase (ADA) levels of pleural effusion in diagnosis of tuberculous pleuritis. Methods: The tuberculosis protein chip and ADA levels were detected individual- ly in 42 patients with tuberculous pleural effusion and 36 patients with malignant pleural effusion. Results: The sensitivity and specific- ity of the tuberculosis protein chip were 69.05% and 91.67% respectively. These ADA levels were 83.33% and 88. 89%. In a com- bination examination, the sensitivity was increased by 95.24%. There was significant difference between the sensitivity of the methods mentioned above. Conclusion: The tuberculosis protein chip combined with ADA could enhance sensitivity for diagnosis tuberculous pleuritis is a method in diagnosing tuberculous pleural effusion.

关 键 词:结核蛋白芯片 腺苷脱氨酶 胸腔积液 

分 类 号:R521.7[医药卫生—内科学]

 

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