脾虚肿瘤患者免疫功能的研究  

Study on Immune Function of Cancer Patients with Spleen-Deficiency Syndrome

作　　者：郁仁存 关崇芬[2] 张建华 徐淑玲[2] 胡玉芳 王迺琦 饶燮卿 林燕[2] 冯灵娟 方晶 

机构地区：[1]北京市中医医院肿瘤科,北京100010 [2]中国中医研究院基础研究所免疫室 [3]北京市中医院肿瘤科,北京100010

出　　处：《中西医结合杂志》1990年第9期535-537,共3页

摘　　要：按中医理论,采用免疫指标(T 细胞亚群、NK 细胞活性及唾液 SIgA 等)及荧光激活细胞分类仪 FACS_(420),研究了脾虚证肿瘤患者的免疫功能,发现其 Th 淋巴细胞减少,NK 细胞杀伤和结合功能降低,唾液的 SIgA 升高,部分病例经有健脾补肾作用的升血汤治疗后,唾液 SIgA 降至正常,NK 细胞杀伤功能明显提高,Th 淋巴细胞有恢复趋势。为中医证型本质研究和中医药在肿瘤治疗中免疫调节作用提供了新资料。According to this study,the immunological function was aberrant in cancer patients with Spleen-deficiency syndrome.The T_H cell in normal persons(n=26) was 30.86±9.70%((?)±S)and in these cases (n=43) was 22.62±9.92%,P<0.002.The cytotoxicity of NK cell in patients (n=59) was 17.65+10.58%,in normal controls (n=43) was 25.51±14.10%.The combining ability of NK cell in patients (n=48) was 39.11±19.43%,the normal persons (n=41) was 55.88±17.94%.It showed that the immune function of the cancer patients with Spleen-deficiency syndrome were markedly lower than that of normal persons.The serum IgA in saliva of patients(n=37)was 0.44±0.17μg/ml.It was much higher than their Of normals'(n=24,0.30±0.06μg/ml),P<0.001.Some patients' NK cell function and the level of SIgA in saliva were recovered to normal after treatment of Shengxue Tang (升血汤)which could strengthen the Spleen and replenish the Kidney.These studies proved that the TCM played an important role for modulating immune function in treating cancer patients.

关 键 词：脾虚证 T细胞亚群 肿瘤 升血汤 

分 类 号：R273[医药卫生—中西医结合]