豨莶草颗粒对小鼠免疫功能影响的实验研究  

Experimental Research of Effect of Herba Siegesbeckiae on Immunological Function of Mice

作　　者：邵南齐[1] 赵敏[1] 王慧琴[1] 朱萱萱[2] 

机构地区：[1]郑州澍青医学高等专科学校基础医学部,河南郑州450064 [2]江苏省中医院临床研究所药理室,江苏南京210029

出　　处：《中华中医药学刊》2012年第8期1872-1874,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：郑州澍青医学高等专科学校资助项目(2010-Y-08)

摘　　要：目的:研究豨莶草对正常小鼠免疫功能的影响。方法:用碳粒廓清法、溶血素抗体测定法、耳廓肿胀法检测豨莶草对小鼠单核吞噬细胞吞噬功能、溶血素抗体生成(HC50)、迟发型超敏反应以及胸腺指数和脾指数的影响。结果:豨莶草使小鼠吞噬指数和吞噬系数、HC50、胸腺指数和脾指数、耳肿胀度均降低,与空白组有显著性差异。结论:豨莶草对正常小鼠的免疫功能具有抑制作用。Objective ：To study the immuno- regulating effect of Herba Siegesbeckiae on normal mice. Methods ：Herba Siegesbeckiae was given, then mononuclear macrophage functions were examined by carbon particle clearance test and anti- body of hemolysin test and the delayed type hypersensitivity（DTH） model induced by dinitrochlorobenzene （DNCB）was was measured by auricle swelling and the indexes of thymus and spleen were calculated. Results ： The phagocytotic ability of macrophages for carbon particle and the indexes of thymus and spleen and the amount of hemolytic antibody and the au- ricle swelling were lower than those of the control group. Conclusion ： Herba Siegesbeckiae can inhibit immunologic function of mice.

关 键 词：豨莶草 吞噬指数 吞噬系数 溶血素抗体 迟发型超敏反应 

分 类 号：R285.5[医药卫生—中药学]