马钱子碱及其中药复方制剂神农丸的抗炎镇痛作用研究  

Anti-inflammatory and Analgesic Effects of Brucine and Shennong Pills

作　　者：赵利民[1] 袁惠中[1] 徐恒卫[1] 崔立新[1] 

机构地区：[1]山东省肿瘤医院,山东济南250117

出　　处：《中华中医药学刊》2012年第8期1874-1876,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:研究马钱子碱及其中药复方制剂神农丸的抗炎镇痛作用。方法:采用二甲苯致小鼠耳肿胀、醋酸致小鼠腹膜毛细血管通透性增加的实验研究神农丸抗炎作用,并与0.9%氯化钠注射液、消炎痛对照。采用醋酸扭体法研究神农丸对小鼠的镇痛作用,并与0.9%氯化钠注射液、阿司匹林对照。结果:马钱子碱2个剂量组(1mg.kg-1,2mg.kg-1)对二甲苯致小鼠耳肿胀具有显著性抑制作用(P=0.024692,P=0.03351);对醋酸致小鼠腹膜毛细血管通透性具有显著性抑制作用(P=0.023174,P=0.028322);对醋酸所致的痛刺激具有非常显著的镇痛作用(P=0.009103,P=0.001572)。神农丸2个剂量组(0.108、0.216g.kg-1)对二甲苯致小鼠耳肿胀具有显著的抑制作用(P=0.047233,P=0.040059);对醋酸致小鼠腹膜毛细血管通透性具有显著的抑制作用(P=0.028309,P=0.037012);对醋酸所致的痛刺激有非常显著的镇痛作用(P=0.002301,P=0.002043)。结论:马钱子碱及其中药复方制剂神农丸具有显著的抗炎作用和非常显著性镇痛作用。Objective：To study the anti-inflammatory and analgesic effects of brucine and Shennong Pills.Method：The ear edema induced by dimethylbenzene and abdominal capillary permeability by acetic acid in mice were used to study the anti-inflammatory effects.The acetic acid writhing method were adopted in the experiment to study the analgesic effects.Results：Brucine（1mg·kg-1,2mg·kg-1） could suppress dimethylbenzene-induced ear edema in mice（P=0.024692,P=0.03351）,reduce the abdominal capillary permeability significantly（P=0.023174,P=0.028322）,and decrease mice writhing（P〈0.05） significantly.While Shennong Pills（0.108g·kg-1,0.216g·kg-1）also could significantly suppress dimethylbenzene-induced ear edema in mice（P=0.047233,P=0.040059）,reduce the abdominal capillary permeability significantly（P=0.028309,P=0.037012）,and decrease mice writhing significantly（P=0.002301,P=0.002043）.Conclusion：Brucine and Shennong Pills have significant anti-inflammatory and analgesic effects.

关 键 词：马钱子碱 神农丸 抗炎作用 镇痛作用 

分 类 号：R285.5[医药卫生—中药学]