点时间尿蛋白与尿肌酐比值在子痫前期患者中的临床应用  

Clinical application of protein-to-creatinine ratio in spot urine samples for preeclampsia

作　　者：匡琳[1] 梁峰冰[1] 杨翠玉[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院妇产科,杭州310016

出　　处：《中华医学杂志》2012年第29期2066-2068,共3页National Medical Journal of China

基　　金：基金项目：浙江省教育厅科研项目（Y20108290）

摘　　要：目的研究点时间尿蛋白与尿肌酐比值（P／Cr）是否可以代替24h尿蛋白定量，用于子痫前期的诊断和病情监测。方法选取2010年1月至2011年12月间在浙江大学医学院附属邵逸夫医院产前检查的100例子痫前期孕妇和36例正常孕妇，对其晨尿P／Cr与24h尿蛋白定量进行相关分析。采用ROC曲线分析确定晨尿P／Cr相对于24h尿蛋白定量为0．3及5g的诊断界点。结果晨尿P／Cr与24h尿蛋白定量高度相关。应用ROC曲线计算晨尿P／Cr相对于24h尿蛋白定量0．3及5g的诊断界点分别为0．34g／g肌酐及2．08g/g肌酐时敏感性和特异性最佳。结论点时间尿P／Cr可以替代24h尿蛋白定量，是子痫前期的诊断、观察、随访工作中可靠、简便的实验方法。Objective To evaluate the clinical application of protein-to-creatinine ratio （P/Cr）in spot urine samples so as to check whether it can replace urine protein excretion in 24 h collections for the diagnosis and screening of preeclampsia. Methods The investigators selected 100 cases of pregnant women with preeclampsia and 36 cases of normal pregnant women examined at Sir Run Run Shaw Hospital over the last two years. The correlations between P/Cr in first morning urine samples and urinary protein excretion in 24 h collections were analyzed. The cutoff values of P/Cr in first morning urine samples for screening preeelampsia of 0.3 g and 5 g in urinary protein excretion in 24 h collections were determined by a receiver operating characteristics （ROC） curve. Results A highly significant correlation existed between P/Cr in first morning urine samples and urinary protein excretion in 24 h collections. By the ROC curve analysis, the P/Cr of 0. 34 g/g and 2. 08 g/g in first morning urine samples represented the most appropriate threshold for detecting the urinary protein excretion of 0. 3 g and 5 g in 24 h collections. Conclusion The P/Cr in spot urine samples can replace urinary protein excretion in 24 h collections. It is a simple and reliable tool of diagnosis and follow-up for preeclampsia.

关 键 词：蛋白尿 肌酐 子痫前期 

分 类 号：R714.245[医药卫生—妇产科学]