TNF-α介导的NF-κB信号通路在类风湿性关节炎血管形成中的作用  

Role of Tumor Necrosis Factor-α Mediated Nuclear Factor Kappa B Signaling Pathway in Antiogenesis in Rheumatoid Arthritis

作　　者：石慧[1] 王丹彤[1] 乌日嘎[1] 李鸿斌[2] 

机构地区：[1]内蒙古医学院第三附属医院(包钢医院),内蒙包头014010 [2]内蒙古医学院第一附属医院,呼和浩特010010

出　　处：《医学综述》2012年第15期2397-2400,共4页Medical Recapitulate

摘　　要：类风湿性关节炎(RA)是一种不明原因的多系统性自身免疫性疾病,以关节滑膜炎、血管翳及对称性、破坏性的关节病变为主要特征。肿瘤坏死因子α(TNF-α)是RA病程中最早产生的细胞因子之一,可与其他细胞因子一起具有促进RA滑膜血管新生。TNF-α介导的核因子κB信号通路在RA炎性反应、血管形成中发挥重要作用,研究此信号通路对RA有重要意义。Rheumatoid arthritis （RA） is a kind of autoimmune disease of unclear causes with multiple systems involved mainly characterized by synovial inflammation, pannus and symmetrical, destructive ar- thritis. Tumor necrosis factor alpha（TNF-α）is one of the earliest cytokines in RA pathogenesis,which together with other cytokines has the RA synovial angiogenesis promotion function. TNF-a induced NF-κB pathway plays an important role in RA inflammatory response and angiogenesis, thus studying the signal pathway is of great significance to RA.

关 键 词：类风湿性关节炎 肿瘤坏死因子α 核因子ΚB信号通路 血管新生 

分 类 号：R593.2[医药卫生—内科学]