半量甘露醇联合七叶皂苷钠治疗早期骨筋膜室综合征的疗效  

Effects of Half Dose of Mannitol Combined with Sodium Aescinate on Early Stage of Compartment Syndrome

作　　者：毕长城 沈正红[1] 周耀君[1] 黄泉川[1] 

机构地区：[1]湖北省远安县人民医院外一科,湖北远安444200

出　　处：《医学综述》2012年第15期2531-2532,共2页Medical Recapitulate

摘　　要：目的探讨半量甘露醇联合七叶皂苷钠对骨筋膜室综合征早期治疗的临床效果。方法选择单一肢体损伤患者36例,随机分为三组:单用七叶皂苷钠组12例(A组),单用半量甘露醇组12例(B组),七叶皂苷钠与半量甘露醇联合应用组12例(C组)。对36例患者的临床指标进行分析,比较肢体治疗前后的患肢周径差、平均治疗时间和临床表现。结果治疗48 h与治疗前周径差值比较差异有统计学意义(P<0.05),组间比较差异有统计学意义(P<0.05)。三组患者治疗时间比较差异有统计学意义,联合组在不同治疗时间段上明显少于单用七叶皂苷钠组和半量甘露醇组。结论联合使用半量甘露醇及七叶皂苷钠较各单用组更有效地缓解骨筋膜室综合征的临床症状,明显减轻患者的痛苦,具有临床使用价值。Objective To study the clinical effect of combined half dose of mannitol with sodium aesci- nate on early stages of compartment syndrome. Methods 36 cases of single-limb injury were randomly divided into three groups-A, B, C group：12 cases of single sodium aesciuate group （group A） , 12 cases of singleuse half the amount of mannitol（ group B）, 12 cases of sodium aescinate in combination with half the amount of mannitol（ group C）, Injured limb circumference, average treatment time and clinical performance of the 36 cases before and after treatment were compared and analyzed. Results The circumference was significantly different（ P 〈 0.05 ） before and 48 hours after treatment, differences between the groups were satististieally significant（ P 〈0.05 ）. Treatment time of three groups were significantly different and combined medication group was obviously shorter than single medication groups. Conclusion The use of half the amount of mannitol and sodium aescinate group is more effective in relief of clinical symptoms of compartment syndrome than single use of either drug,which significantly reduces the suffering of patients with clinical value.

关 键 词：骨筋膜室综合征 半量甘露醇 七叶皂苷钠 

分 类 号：R863[医药卫生—临床医学]