磁性温敏复合微球的制备及磁场中的释药行为  

Preparation of Magnetic Temperature-responsive Composite Microspheres and Their Drug-release Behaviors Under AC Magnetic Field

作　　者：姚爱华[1,2] 陈绮[1] 艾凡荣[1,3] 王德平[1,2] 

机构地区：[1]同济大学材料科学与工程学院,上海201804 [2]同济大学先进土木工程材料教育部重点实验室,上海201804 [3]南昌大学机电工程学院,江西南昌330031

出　　处：《同济大学学报（自然科学版）》2012年第8期1239-1243,共5页Journal of Tongji University:Natural Science

基　　金：国家自然科学基金(50702037)

摘　　要：采用无皂乳液聚合的方法将Fe3O4与温敏性N-异丙基丙烯酰胺-丙烯酰胺共聚物[P(NIPAAm-co-Am)]复合,制备了具有核壳结构的磁性温敏复合微球,并研究了其在60kHz,6.5kA·m-1交变磁场作用下的磁热性能和药物缓释行为.结果表明,所制备的Fe3O4/P(NIPAAm-co-Am)复合微球具有良好的磁热性能,20min内即可使自身温度升高到温敏聚合物的最低临界溶解温度(LCST),约为42°C.复合微球在连续和间歇磁场作用下的药物释放行为显示,间歇性施加磁场能够延长药物的释放周期,而且能够有效增大药物的积累释放量.因具有良好的磁热和药物缓释性能,所制备的聚合物微球有望同步实现肿瘤热疗和化疗药物的可控释放.Magnetic and temperature-responsive polymer microspheres, consisting of superparamagnetic Fe3 04 nanopaticles and temperature-responsive poly （ N - isopropylacrylamide- coacrylamide ） [P（NIPAAm- co-Am）] microgel, were prepared by soap-free emulsion free copolymerization. Their heating generation abilities and drug release behaviors were investigated under an AC magnetic field of 60 kHz and 6. 5 kA ~ m-1. Results show that the as-synthesized Fea O4/P（NIPAAm-co-Am） composite microspheres exhibite high heating generation ability. The temperature of 42 ~C, which is close to the lower critical solution temperature （LCST） of the temperature-responsive polymer, appears after the composite microspheres being exposed to an AC magnetic field for 20 min. The drug release profiles show that longer release duration and larger overall release can be achieved by intermittent application of a magnetic field as compared to continuous magnetic field. With high heating generation ability and controlled drug release property, Fe3 04/P（NIPAAm- co- Am） polymer microspheres are promising for the combination of tumor hyperthermia and controlled release of chemotherapy drugs.

关 键 词：磁性复合微球 药物缓释 FE3O4 P(NIPAAm-co-Am) 

分 类 号：O614.8[理学—无机化学] O648.17[理学—化学]