3种药物联合治疗糖尿病周围神经病变50例  

Effect of Combined Use of α-lipoic Acid,Lipo PGE1 and Danhong on Treatment of Diabetic Peripheral Neuropathy

作　　者：刘超[1] 杜万红[1] 郑桃林[1] 

机构地区：[1]解放军第163医院老年病科,长沙410003

出　　处：《医药导报》2012年第8期1023-1025,共3页Herald of Medicine

摘　　要：目的观察α-硫辛酸、前列地尔、丹红注射液联合治疗糖尿病周围神经病变(DNP)的效果。方法将100例2型糖尿病并发DNP患者随机分成两组各50例,均严格控制饮食,适量运动,口服降糖药物或注射胰岛素控制血糖,α-硫辛酸0.6 g+0.9%氯化钠注射液250 mL静脉滴注,qd。治疗组加用前列地尔10μg静脉注射,qd;丹红注射液30 mL+0.9%氯化钠注射液250 mL静脉滴注,qd。均治疗2周。比较治疗前后密歇根症状评分及运动、感觉神经传导速度(MNCV、SNCV)。结果治疗组改善糖尿病DNP自觉症状总有效率(90.0%)显著高于对照组(64.0%)(P<0.01);两组神经传导速度均明显改善,治疗组优于对照组(P<0.01)。治疗组治疗后各症状密歇根评分均低于治疗前。对照组感觉减退、麻木症状密歇根评分低于治疗前。治疗组治疗后刺痛、烧灼感密歇根评分低于对照组,均差异有统计学意义(P<0.05)。治疗组治疗后正中神经和腓神经的MNCV、SNCV均高于本组治疗前,且高于对照组治疗后,均差异有统计学意义(P<0.01)。结论α-硫辛酸、前列地尔、丹红注射液联合治疗DNP疗效显著。Objective To observe the effect of combined use of α-lipoic acid,Lipo PGE1 and danhong on the treatment of diabetic peripheral neuropathy.Methods One hundred patients with diabetic peripheral neuropathy were randomly and evenly divided into treatment group and control group.All the patients were administered oral antidiabetic drug or injected with insulin to control the blood glucose level.Additionally,the treatment group was given combined use of α-lipoic acid,Lipo PGE1 and danhong,but the control group received α-lipoic acid for treatment.Michigan symptom score,motor nerve conduction velocity（MNCV） and sensory nerve conduction velocity（SNCV） in both groups were compared before and after the treatment.Results After the treatment for 14 days,the subjective symptoms and signs were significantly improved with a total effective rate of 90.0% in the treatment group versus 64.0% in the control group.Compared with the control group,the total effective rate of treatment group was significantly higher（P〈0.01）.NCV of both groups was significantly improved after the treatment,and the NCV of the treatment group was significantly higher than that of the control group（P〈0.01）.In the treatment group,Michigan scores of all symptoms after the treatment were lower than those before the treatment（P〈0.05）.In the control group,Michigan scores of hypesthesia and numbness after the treatment were lower than that before the treatment,and after the treatment the Michigan scores of prickling and burning of the treatment group were significantly lower than that of the control group（both P〈0.05）.After the treatment,MNCV and SNCV of the treatment group were significantly higher than those before the treatment,and significantly higher than those of the control group as well（P〈0.01）.Conclusion Combined use of α-lipoic acid,Lipo PGE1 and danhong is effective in the treatment of diabetic peripheral neuropathy.

关 键 词：前列地尔 Α-硫辛酸 丹红注射液 糖尿病 周围神经病变 

分 类 号：R58[医药卫生—内分泌] R977[医药卫生—内科学]