维持透析的终末期肾脏病患者血清胱抑素-C与肌酐的相关性分析  

Analysis of the correlation between levels of Cystatin-C and Creatinine in ESRD patients maintaining dialysis

作　　者：唐杏明[1] 关晓东[1] 魏丽萍[1] 朱学海[1] 

机构地区：[1]中山大学附属东华医院肾内科,广东东莞523110

出　　处：《右江医学》2012年第4期475-477,F0004,共4页Chinese Youjiang Medical Journal

摘　　要：目的分析维持性非卧床腹膜透析(CAPD)患者和维持性血液透析(HD)患者的血清胱抑素-C(Cys-C)水平,比较不同透析方式对Cys-C的影响;并进一步探讨Cys-C与血肌酐(Scr)的相关性,探索判断残存肾功能的新型标志物。方法选取肾内科病情稳定的CAPD患者160例归为腹膜透析组,病情稳定的HD患者80例归为血液透析组。两组患者每1～3个月抽血一次,采用胶乳凝聚法检测血清Cys-C浓度,采用苦味酸法测定血清Scr,比较两组患者的Cys-C、Scr水平,并分析两指标的相关性。结果腹膜透析组血清Scr、Cys-C水平均显著高于血液透析组(P<0.01),两个指标的比值进一步比较,腹膜透析组仍高于血液透析组(P<0.05)。对腹膜透析组、血液透析组及两组合并行Pearson相关分析,发现Scr和Cys-C呈线性正相关(P<0.01)。进一步行简单线性回归,回归方程估计为:Scr=389.93+98.49Cys-C。结论腹膜透析对终末期肾脏病(ESRD)患者Cys-C的清除能力低于血液透析;Cys-C可作为判断维持透析的ESRD患者残存肾功能的新型标志物。Objective To analyze levels of Cystatin-C in CAPD（Continuous Ambulatory Peritoneal Dialysis）pa- tients and HD（Hemodialysis） patients and to compare the effects of different dialysis means on Cystatin-C. Further in- vestigation of the correlation between Cystatin-C and Creatinine was made to explore the new marker of residual renal function. Methods 160 CAPD patients in stable condition were observed as the Peritoneal Dialysis Group. 80 HD pa- tients in stable condition were selected as the HD Group. Blood drawing was carried out every 1 to 3 months for both two groups patients. Density of Cystatin-C was detected by latex condensed method while Creatinine by picric acid method. Levels of Cystatin-C and Creatinine were compared and analyzed. Results The Peritoneal Dialysis Group had higher levels of Cystatin-C and Creatinine than the HD Group（ P 〈0.01）. Further comparison showed that the Peri- toneal Dialysis Group did have higher levels （ P 〈0.05）. Analysis was given to the two groups and Pearson analysis was given to the combination of these two groups. The analysis showed that the level of Cystatin - C was positively linearcorrelated with Creatinine and the linear regression formula was Ser= 389.93＋ 98.49Cys. Conclusion Peritoneal di- alysis has lower ablility for eliminating Cystatin-C in ESRD patients than hemodialysis. Cystatin-C can be used as a new marker of residual renal function.

关 键 词：终末期肾脏病 维持性非卧床腹膜透析 血液透析 胱抑素-C 肌酐 

分 类 号：R459.5[医药卫生—治疗学]