京尼平苷透皮制剂抗炎镇痛作用的研究  

Expermiental Research on Anti-Inflammatory and Analgesic Effects of Geniposide Cream and Microemulsion

作　　者：施华平[1] 张杰[2] 游伟良[2] 曹维[3] 孙敏捷[2] 

机构地区：[1]南京中医药大学基础医学院,南京210046 [2]中国药科大学药学院药剂教研室,南京211198 [3]国家知识产权局专利局专利审查协作江苏中心,苏州215011

出　　处：《药学与临床研究》2012年第4期297-300,共4页Pharmaceutical and Clinical Research

基　　金：江苏省中医药管理局科研项目(LB09015)

摘　　要：目的:考察京尼平苷乳膏和京尼平苷微乳的抗炎镇痛作用。方法:乳化法制备京尼平苷乳膏和京尼平苷微乳;热板测痛法和醋酸诱导的扭体法考察制剂的镇痛效果;采用二甲苯致炎和角叉菜胶致脚趾肿胀法考察制剂的抗炎效果,并与市售的抗炎和镇痛的制剂进行了比较。结果:京尼平苷乳膏和京尼平苷微乳具有抗炎镇痛的作用,乳膏剂型的效果更为显著,和市售产品的效果接近或者是更强。结论:将京尼平苷制成透皮制剂具有抗炎和镇痛的作用,其中乳膏的效果更好,为临床应用提供了实验依据。Objective： To study the analgesic and anti-inflammatory effects of geniposide cream and microemulsion. Methods： The o/w type cream and microemulsion of geniposide were prepared and applied to tests of plate heating, writhing response induced by acetic acid, ear swollen of mice induced by xylene and foot swollen in mice induced by carrageenan, in comparison with the pharmaceutical market products. Result： Compared with the pharmaceutical market products, geniposide cream and microemulsion all showed analgesic effects and anti-inflammatory effects, but the geniposide cream was more effective and had no skin irritation. Conclusion： Geniposide cream and microemulsion have certain analgesic and anti- inflammatory effects, while the cream is better.

关 键 词：京尼平苷 乳膏 微乳 抗炎 镇痛 

分 类 号：R965.1[医药卫生—药理学]