骨碎补外用对环磷酰胺致小鼠斑秃模型的影响  

Experimental effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in mice

作　　者：黄云英[1] 张德芹[1] 沈丽[1] 王雪妮[1] 杜娟[1] 王元元[1] 

机构地区：[1]天津中医药大学中医药研究院方剂学教育部重点实验室,天津300193

出　　处：《天津中医药》2012年第4期375-377,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家科技支撑计划项目(2008BA153B09)

摘　　要：[目的]考察骨碎补外用对环磷酰胺致C57BL/6小鼠斑秃模型的影响。[方法]采用环磷酰胺腹腔注射建立C57BL/6小鼠斑秃模型,观察骨碎补外用对小鼠毛囊组织学变化和血清细胞间黏附蛋白(ICAM-1)、内皮细胞-白细胞黏附分子-1(ELAM-1)水平的影响。[结果]骨碎补外用能使实验性斑秃模型小鼠血清ICAM-1和ELAM-1水平降低,毛囊数增多(P<0.05或P<0.01)。[结论]骨碎补外用能够抑制毛囊进入退行期,对斑秃模型小鼠具有治疗作用。[Objective] To investigate the effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in C57BL/6 mice. [Methods] Severe alopecia was induced by cyclophosphamide in these mice. The hair growth and histological changes were observed in the back skin of them. The levels of ICAM-1 and ELAM-1 in the serum were determined by ELISA. [Results] The levels of ICAM-1 and ELAM- 1 in herbal group were lower than that in the control group. The nutrition of hair follicles was also improved. [Conclusions] The extract from Drynaria fortunei has a promoting effect on the hair growth by its external application.

关 键 词：骨碎补 外用 环磷酰胺 斑秃 

分 类 号：R285.5[医药卫生—中药学]