糖脂清过柱前后对KK-A^y小鼠血糖血脂药效学影响对比实验  

Comparative experiment of TZQ on abnormal glucose and lipid metabolism in KK-Ay mice before and after passing macroporous resin

作　　者：李玉红[1] 刘虹[1] 王茜[1] 李俊青[1] 曾森[1] 张德芹[1] 胡利民[1] 

机构地区：[1]天津中医药大学中医药研究院天津市中药药理学重点实验室方剂学教育部重点实验室,天津300193

出　　处：《天津中医药》2012年第4期384-388,共5页Tianjin Journal of Traditional Chinese Medicine

基　　金：科技部国际科技合作项目(2009DFA31070)

摘　　要：[目的]对比治疗2型糖尿病新药糖脂清经过大孔树脂处理与未经过大孔树脂(过柱前后)在降血糖、调节血脂药效学方面有无差异。[方法]应用糖尿病KK-Ay小鼠,大孔树脂处理前、后糖脂清8、4、2 g/kg灌胃给药5周,以拜唐苹为对照药,评价并比较过柱前、后糖脂清对小鼠血糖、血脂等的影响。[结果]糖脂清过柱复方与未过柱复方均有降低小鼠饮水量、尿量趋势;能显著降低小鼠非禁食及灌胃蔗糖后30、60、120 min血糖浓度,降低血清甘油三酯(TG)、胰岛素含量,改善胰岛素抵抗。[结论]糖脂清中山楂叶、丹参、赤芍经大孔树脂处理后没有降低整体药效。[Objective] To compare the effects of Tangzhiqing（TZQ）, a new traditional Chinese anti-diabetic prescription containing five ingredients, on abnormal glucose and lipid metabolism before and after passing macroporous resin in KK-Ay mice. [Methods] KK-Ay diabetic mice were administrated with TZQ before and after passing macroporous resin at the dose of 8, 4, 2 g/kg for 5 weeks. Glucobay was taken as control. The effect of TZQ on blood glucose and Lipid in mice before and after passing macroporous resin was observed. [Results] Both kinds of TZQ tended to reduce fresh water intaking, urine volume of KK-Ay mice. They could also significantly reduce the non-fasting glucose and glucose at 30, 60, 120 min after sucrose was given orally. They could decrease TG, serum insulin and improve the insulin resistance. [Conclusion] TZQ, made up by Hawthorn Leaf, Danshen root, Red Paeony Root and so on, does not decrease the pharmacologyic effect after processing by macroporous resin.

关 键 词：山楂叶 丹参 赤芍 大孔树脂 药效学 

分 类 号：R285.5[医药卫生—中药学]