益智亲水凝胶骨架片的制备  

Preparation of Yizhi hydrogel matrix tablets

作　　者：武慧超[1] 陆洋[1] 杜守颖[1] 翟永松[2] 蔡程博[1] 赵静宜[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]首都医科大学,北京100069

出　　处：《中华中医药杂志》2012年第8期2069-2072,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金："重大新药创制"科技重大专项(No.2009ZX09502-008;No.2009ZX09308-003);国家自然科学基金面上项目(No.81073057);北京中医药大学自主选题(No.JYBZZ-XS036);北京中医药大学创新团队发展计划(No.2011-CXTD-13)~~

摘　　要：目的:制备益智亲水凝胶骨架片。方法:以羟丙甲基纤维素为骨架材料制备亲水凝胶骨架片,以栀子苷、人参皂苷Rg1、人参皂苷Rb1和三七皂苷R1为评价指标,考察各因素对益智亲水凝胶骨架片体外释放的影响,优化处方和工艺。结果:辅料用量为20%且HPMCK15M:HPMCK4M为1:13时,以粉末直接压片法制备的益智亲水凝胶骨架片在12h内持续释药,达到缓释效果,且释药曲线平稳,3批验证f2因子均大于50。结论:以羟丙甲基纤维素为骨架材料,粉末直接压片可制得缓释效果理想的益智亲水凝胶骨架片。Objective：To prepare Yizhi hydrogel matrix tablets.Methods：Using hydroxyl propyl methyl cellulose（HPMC） as the main carrier,gardenin,Panax Notoginseng Saponins R1,ginsenoside Rg1,and ginsenoside Rb1 were used to investigate the influence of factors in vitro releasing,to optimize formulations and preparation.Results：As 20% of the amount of materials and HPMCK15M：HPMCK4M=1：13 were used,Yizhi hydrophilic matrix prepared by direct powder compression can sustained release in 12h,displaying constant release effect,and the release curve smooth,three batches of authentication f2 factors were greater than 50.Conclusion：HPMC as matrix material,powder pellets can be obtained the desired effect of sustained-release Yizhi hydrophilic matrix.Yizhi hydrophilic matrix prepared by using HPMC as matrix material and using direct powder compression as preparation method displayed constant release profile.

关 键 词：亲水凝胶骨架片 羟丙甲基纤维素 粉末直接压片 三七总皂苷 栀子苷 

分 类 号：R94[医药卫生—药剂学]