丹参酮Ⅱ_A自微乳制剂的体外释放和在体肠吸收评价  

Assessment of tanshinone Ⅱ_A self-microemulsifying preparation with drug release in vitro and intestinal absorption in situ

作　　者：赵晓旭 李江英 崔延堂[1] 孙哲[1] 张亚军[1] 

机构地区：[1]西北大学生命科学学院,西安710069 [2]西安市中医医院,西安710001

出　　处：《中华中医药杂志》2012年第8期2189-2191,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：陕西省教育厅专项科研计划项目(No.08JK478)~~

摘　　要：目的:对丹参酮ⅡA自微乳制剂进行体外释放和在体肠吸收评价。方法:以反向透析法进行丹参酮ⅡA自微乳制剂的体外释放度考察;采用大鼠在体小肠单向灌流实验模型,比较丹参酮ⅡA自微乳制剂和混悬液在大鼠肠道的吸收差异。结果:丹参酮ⅡA自微乳制剂45min内的累积释放度可达85%以上,而混悬液在90min内溶出度小于30%。大鼠在体肠吸收结果显示,丹参酮ⅡA自微乳制剂的吸收速率常数(Ka)和表观吸收系数(Papp)显著高于混悬液(P<0.01)。结论:自微乳制剂可显著提高丹参酮ⅡA的体外溶出和体内肠吸收程度。Objective：To evaluate the drug release characteristics in vitro and the intestinal absorption behavior in situ of tanshinone ⅡA self-microemulsifying preparation（TA-SMP）.Methods：In vitro release studies were conducted by reverse dialysis technique.Rat single-pass intestinal perfusion technique was employed and the absorption properties of TA-SMP were evaluated by comparison with the suspension.Results：The dissolution of TA-SMP at 45 min was much higher（more than 85%） than that of the suspension（less than 30%）.The values of the absorption rate constant（Ka） and the intestinal apparent permeability coefficient（Papp） of Tan-SM were significantly higher than that of the suspension（P〈0.01）.Conclusion：The self-microemulsifying delivery systems can significantly increase the dissolution of tanshinone ⅡA in vitro and absorption rate in rat intestine in situ.

关 键 词：丹参酮ⅡA 自微乳 释放度 单向灌流法 在体肠吸收 

分 类 号：R283[医药卫生—中药学]