全脑血管造影术前、后血浆ET-1、vWF水平的初步探讨  

Levels of plasma endothelin-1 and von willebrand factor undergoing cerebral angiography:a pilot study

作　　者：付棉[1] 秦超[1] 程道宾[1] 赵伟佳[1] 梁志坚[1] 刘竞丽[1] 梁明辉[1] 陈相任[1] 

机构地区：[1]广西医科大学第一附属医院神经内科,南宁530021

出　　处：《重庆医学》2012年第23期2364-2365,2368,共3页Chongqing medicine

摘　　要：目的探讨脑血管造影术(DSA)前、后血浆内皮素-1(ET-1)及血管性血友病因子(vWF)的水平变化,初步探讨DSA对血管内皮细胞的影响。方法测定106例缺血性脑血管病患者术前、术后即刻、术后1d血浆ET-1、vWF的含量。根据脑血管狭窄病变程度分为A、B两个亚组。结果 DSA术后血浆ET-1水平均明显升高,ET-1在术后即刻有明显升高(549.45±109.37)pg/mL,术后1d有所下降(519.71±111.68)pg/mL,但仍高于术前水平(500.08±112.23)pg/mL,3个时间点血浆ET-1水平有明显差异。血浆vWF水平术后未观察到明显升高。不同狭窄程度亚组相比,病变较重的亚组术前ET-1和vWF水平均较高,且术后也持续在较高水平。结论血浆ET-1和vWF水平可能与动脉狭窄程度相关;术后ET-1的升高提示DSA术可能对血管内皮细胞造成一定的损伤。Objective Levels of plasma endotheliwl and yon willebrand factor（vWF） of patients with ischemic cerebrovascular disease undergoing cerebral angiography were investigated. The aim of this study was to investigate the effects of cerebral angiogra- phy on vascular endothelial cell. Methods Plasma levels of endothelin 1 and vWF were measured by enzyme linked immunosorbent assay in 106 patients before and immediately as well as one day after cerebral angiography. The patients were divided into A and B groups hy the degree of stenosis. Results Plasma levels of endothelin-1 significantly increased immediately（549.45 ± 109.37 pg/ mL, P〈0.05） and one day（ 519.71 ± 111.68 pg/mL, P〈0.05） after cerebral angiography compared with before the procedure（ 500. 08± 112.23 pg/mL）. The elevated levels of vWF was not observed. Compared with the non-severe stenosis,the patients with more severe stnosis exhibited significantly higher plasma levels of ET-1 and vWF both before and after cerebral angiography. Conclusion The levels of ET-1 and vWF probably correlated to the degree of stenosis. The marked and sustained increase endothelin-1 plasma levels after cerebral angiography is probably related to mechanical endothelial injury by the procedure.

关 键 词：脑血管造影术 内皮素-1 血管性血友病因子 脑血管狭窄 

分 类 号：R816.1[医药卫生—放射医学]