芳香硝基化合物原位液相加氢一锅法合成喹啉类化合物  

In-Situ Liquid Phase Catalytic Hydrogenation for One-Pot Synthesis of Quinolines from Aromatic Nitro Compounds

作　　者：顾辉子[1] 许响生[1] 陈傲昂[1] 严新焕[1] 

机构地区：[1]浙江工业大学绿色化学合成技术国家重点实验室培育基地,浙江杭州310014

出　　处：《催化学报》2012年第8期1423-1426,共4页

基　　金：国家自然科学基金(20676124;21076197);浙江省自然科学基金项目(Y4090440);浙江省钱江人才项目(2010R10038)~~

摘　　要：以芳香硝基化合物为起始原料,以2%Pt-Sn/γ-Al2O3为催化剂,采用原位液相加氢法可以一锅法合成喹啉类化合物,考察了Pt/Sn摩尔比、反应温度、原料浓度和水含量等对反应性能的影响.结果表明,在Pt/Sn摩尔比0.5,220oC,5.0MPa,原料浓度6%,水含量30%及反应物停留时间为72s的条件下,生成产物6-甲氧基-2-甲基喹啉的收率可达72%.A new hydrogenation system was proposed for the synthesis of quinolines. Aromatic nitro compounds and ethanol/water solution were used as the starting materials, and Pt-Sn/7-A1203 was the catalyst. The quinolines were synthesized by the one-pot method with an in-situ liquid phase hydrogenation system. The reaction results showed that the Pt/Sn molar ratio and the reaction conditions including tem- perature and the concentration of the substrate and water played an important role on the yield of the quinolines. When the Pt/Sn molar ratio was 0.5, under the conditions of 220℃, 5.0 MPa, 6% substituted nitrobenzene concentration with 70% EtOH and 30% H20 solution, the total yield of 6-methoxyl-2-methyl quinoline reached 72.0%.

关 键 词：铂 锡 氧化铝 原位液相加氢 芳香硝基化合物 喹啉 

分 类 号：TQ25[化学工程—有机化工]