硝苯吡啶对低氧性肺动脉高压的疗效观察  

Treatment Effect of Nifedipine on Hypoxic Pulmonary Hypertension at High Altitude

作　　者：崔建华[1] 杨海军[1] 高亮[1] 阳盛洪[1] 马广全[1] 曹荣成[1] 王宏运[1] 王琰[1] 黄岚[2] 

机构地区：[1]解放军第18医院全军高山病防治研究中心,844900 [2]第三军医大学新桥医院心血管内科,400038

出　　处：《高原医学杂志》2012年第1期5-7,共3页Journal of High Altitude Medicine

摘　　要：目的:探讨硝苯吡啶对低氧性肺动脉高压(HPH)的疗效观察。方法:在海拔5 000 m以上高原,对临床确诊的20例HPH患者口服硝苯吡啶10mg/次,每日2次,服用3个月,治疗前后采用超声心动图检测右室舒张末前后径(RVED)、右室前壁厚度(RVAW)、右室流出道(RVOT)、肺动脉主干内径(MPA)和三尖瓣反流,同时采血检测超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)及一氧化氮合酶(NOS)的含量。结果:治疗后较治疗前RVED、RVAW、RVOT、MPA降低,有非常显著性差异(P<0.05或0.01);三尖瓣反流发生率明显降低(P<0.01);治疗后较治疗前SOD、NOS、NO增高,MDA降低,有显著性差异(P<0.05或0.01)。结论:硝苯吡啶对低氧性低肺动脉高压具有一定的治疗作用,除钙拮抗外,还存在抗氧化作用。Objective： To observe the treatment efficacy of nifedipine on hypoxic pulmonary hypertension （HPH） at high altitude. Methods：20 volunteers who had been identified to have clinically HPH at 5 000m alti- tudes, were collected in this study. They were administered orally nifedipine, 10mg / time, 2 times / d for three months, and accepted the echocardiograph to evaluate right ventrieular end -diastolic dimension （RYED）, right ventricular anterior wall （RVAW）, right ventricular outflow tract （RVOT）, Main pulmonary artery diameter （MPA） and tricuspid regurgitation （TR） before and after treatment; meanwhile, level of superoxide dismutase （SOD） , malonaldehyde （MDA） , nitrogen oxide （NO） , nitric oxide synthase （NOS） were examined. Results： RVED, RVAW, RVOT, MPA, TR and MDA level were significantly decreased after treatment compared with those before treatment （ P 〈 0.05 or 〈 0.01 ） ; Level of SOD, NOS and NO were significantly higher after treatment than those before treatment （P 〈0.05 or 〈0.01 ））. Conclusions：Nifedipine could degrade hypoxie pulmonary hyper- tension at high altitude duo to its effect of anti -oxidation and calcium antagonism.

关 键 词：高原 低氧性肺动脉高压 硝苯吡啶 超声心动图 自由基代谢 

分 类 号：R543.2[医药卫生—心血管疾病] R969.4[医药卫生—内科学]