地高辛联合呋塞米治疗慢性心力衰竭的疗效与安全性评价  

Safety and Efficacy Assessment of Digoxin Combined with Furosemide for Chronic Cardiac Failure

作　　者：宋敏[1] 陈刚[2] 李耀军[1] 谭顺林 

机构地区：[1]四川省资阳市第一人民医院药剂科,641300 [2]四川省资阳市第一人民医院ICU,641300 [3]四川省资阳市第一人民医院心内科,641300

出　　处：《临床合理用药杂志》2012年第24期28-29,共2页Chinese Journal of Clinical Rational Drug Use

基　　金：资阳市科技局科学技术发展计划项目([2009]61)

摘　　要：目的观察地高辛联合呋塞米维护使用治疗慢性心力衰竭的安全性与疗效。方法收集2009—2011年我院门诊或入院慢性心力衰竭患者,在病情稳定后常规给予ACEI及β受体阻滞剂等药物基础上采用地高辛与呋塞米联合维护治疗患者60例,其中在院24例,门诊36例,联合使用疗程均在7d以上,分析地高辛与呋塞米联合维护治疗的安全性与临床疗效。结果地高辛0.125mg联合呋塞米20mg隔日1次口服维护治疗方式洋地黄中毒发生率、电解质异常发生率最低;而心功能改善总有效率达75.0%。结论小剂量地高辛联合呋塞米隔日使用维护治疗慢性收缩性心力衰竭患者安全、有效。Objective To evaluate the safety and efficacy of digoxin combined with furosemide maintenance treatment of chronic cardiac failure. Methods Cases of outpatient or hospitalized patients with chronic cardiac failure, from 2009 to 2011 in our hospital, were collected. After the patients condition was stable, more than 7 days＇ digoxin combined with furosemide was given to 60 patients, 24 of which were hospitalized and the other 36 cases were outpatients, on the basis of routine drugs treat- ment such as ACEI and β receptor retardant. Safety and efficacy of digoxin combined with furosemide were analyzed. Results Oral aaministration O. 125 mg digoxin combined with 20 mg furosemide quote of the day had the lowest incidence of digitalism and abnormality of electrolyte, moreover, effective rate of improved cardiac function was near 75.0%. Conclusion It＇s safe and effective for patients with chronic cardiac failure treated by taking orally low dosage of digoxin combined with furosemide quote of the day.

关 键 词：地高辛 呋塞米 心力衰竭 治疗结果 

分 类 号：R541.6[医药卫生—心血管疾病]