甘精胰岛素联合瑞格列奈治疗2型糖尿病的Meta分析  

Glargine insulin plus repaglinide in the treatment of type 2 diabetes Meta analysis

作　　者：陆红[1] 胡学军[2] 黄国福[3] 

机构地区：[1]新疆医科大学第五附属医院门诊部,乌鲁木齐830011 [2]新疆医科大学第五附属医院肿瘤外科,乌鲁木齐830011 [3]新疆医科大学第五附属医院肿瘤内科,乌鲁木齐830011

出　　处：《新疆医科大学学报》2012年第8期1038-1041,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金项目(30860080)

摘　　要：目的评价甘精胰岛素联合瑞格列奈治疗2型糖尿病的文献临床应用的价值。方法分别对中国生物医学文献数据库、中国学术期刊网络出版总库、维普资讯-中文科技期刊数据库、万方数据库进行甘精胰岛素联合瑞格列奈治疗2型糖尿病的文献检索,采用RevMan5.1统计软件包对符合纳入标准的文献进行Meta分析。结果共计纳入29篇文献,甘精胰岛素联合瑞格列奈治疗8、12w后空腹、餐后2h血糖明显改善并且可以减少糖化血红蛋白量,前后对照差异有统计意义(P<0.05);治疗24w前后空腹、餐后2h血糖比较差异无统计学意义(P>0.05),然而治疗24w前后糖化血红蛋白的比较差异有统计学意义(P=0.002);甘精胰岛素联合瑞格列奈与诺和灵30R比较治疗2型糖尿病在空腹血糖、餐后2h血糖、糖化血红蛋白3项指标比较差异均有统计学意义(P<0.05)。结论甘精胰岛素联合瑞格列奈可以有效控制空腹、餐后2h的血糖,并且可以减少糖化血红蛋白的含量;甘精胰岛素联合瑞格列奈较控制空腹、餐后血糖、糖化血红蛋白优于诺和灵30R。Objective To evaluate glargine insulin plus repaglinide in the treatment of type 2 diabetes literature value of the clinical application.Methods Chinese Biomedical Literature Database,Chinese Academic Journal Web publishing pool,Information-Chinese Science and Technology Periodical Database,Wanfang Database were used to do literature search on insulin glargine combined with repaglinide in type 2 diabetes with RevMan5.1 statistical softwarepackage,Meta-analysis was used to analyze the literatures consistent with the inclusion criteria.Results A total of 22 articles were included insulin glargine combined repaglinide 8 and 12 weeks after fasting and postprandial glucose improved significantly and can reduce the amount of glycosylated hemoglobin,the difference was statistically significant（P0.05）;treatment of 24 weeks of fasting,2-hour postprandial blood glucose difference was no statistically significant（P0.05）,however,there was significant differences of change in glycosylated hemoglobin before and after 24 weeks of treatment（P=0.002）.Three indicators of insulin glargine combined with repaglinide and Novolin 30 R to compare the treatment of type 2 diabetes differences were statistically significant（P0.05） from fasting glucose,postprandial 2 hours after treatment glycosylated hemoglobin change.Conclusion Insulin glargine joint repaglinide can be an effective control of fasting,2-hour postprandial blood glucose and glycosylated hemoglobin levels can be reduced;Glargine joint repaglinide compared with Novolin 30R can better control the fasting and postprandial blood glucose,glycosylated hemoglobin.

关 键 词：甘精胰岛素 瑞格列奈 2型糖尿病 META-分析 

分 类 号：R587.1[医药卫生—内分泌] R453[医药卫生—内科学]