银杏叶提取物对糖尿病的药效学研究  

The Pharmacodynamic Studies of Ginkgo biloba Extract on Diabetes Mellitus

作　　者：奚涛[1] 王玲玲[1] 

机构地区：[1]中国药科大学生物技术中心,南京210009

出　　处：《中国药科大学学报》2000年第4期285-288,共4页Journal of China Pharmaceutical University

摘　　要：观察了银杏叶提取物 ( EGb)对糖尿病大鼠的治疗作用。结果表明 EGb能降低正常大鼠血糖 ,但无明显的量效关系 ;使四氧嘧啶糖尿病大鼠血糖下降 ,血清胰岛素升高。对糖尿病大鼠的血脂代谢有显著的改善作用 ,使 HDL升高而 TG、TC、LDL值显著降低 ( P<0 .0 1 )。EGb也能显著降低血清和组织中的脂质过氧化产物丙二醛 ( MDA)含量 ( P<0 .0 1 )。因此 EGb对糖尿病有一定的治疗作用 ,其作用可能与 EGb促进胰岛 β细胞分泌胰岛素增多 ,清除自由基 ,改善血脂代谢等有关。The therapeutic effects of Ginkgo biloba extract(EGb) on alloxan diabetes mellitus(DM) rats were studied. After ip administration of EGb for 4 weeks in normal and DM rats, the fasting blood glucose(FBG), serum insulin(Ins), lipemia and the product of lipid peroxidization malondialdehyde(MDA) were determined. EGb showed hypoglycemic effect on normal rats and decreased significantly FBG and increased DM rats′ serum Ins. It could markedly ameliorate lipemia metabolism, increasing HDL and decreasing TG, TC and LDL (P<0.01). EGb could also decrease the level of MDA in serum and tissue (P<0.01). EGb has some therapeutic effects on DM rats, possibly concerning with more secretion of Langerhans′ islet β cell, free radical elimination and amelioration of lipid metabolism.

关 键 词：银杏叶提取物 糖尿病 指质过氧化 药数学 

分 类 号：R285[医药卫生—中药学]