乙型肝炎肝硬化患者继发糖代谢紊乱的相关因素分析  

The related factors analysis of hepatitis B liver cirrhosis patients with secondary glucose metabolism disorders

作　　者：张东兰[1] 郑翠玲[1] 王淑香[1] 张志刚[1] 

机构地区：[1]滨州市人民医院感染一科,山东省滨州256610

出　　处：《中国基层医药》2012年第17期2575-2576,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨乙肝肝硬化患者继发糖代谢紊乱的相关危险因素。方法选取18d例乙型肝炎肝硬化患者为研究对象，依据75g口服葡萄糖耐量（OGTT）试验结果分为三组[糖耐量正常组（NGT组）、糖耐量异常和空腹血糖调节受损组（IGR组）、糖尿病组（DM组）]，比较三组患者一般资料、实验室检查和病毒载量等项目。结果（1）DM组、IGR组与NGT组比较，年龄、腰围、体质量、体质量指数以及乙型肝炎病毒载量差异均有统计学意义（均P〈0．05），DM组与IGR组比较，所有指标差异均无统计学意义（均P〉0．05）。（2）随着糖代谢异常加重，NGT组、IGR组以及DM组的HBsAg、HBeAg和前s1抗原阳性率均逐渐升高（均P〈0．05）。结论体质量指数和乙型肝炎病毒载量是乙型肝炎肝硬化患者继发糖代谢紊乱的相对独立危险因素，与继发糖尿病的发生率正相关，但性别、年龄、血脂与继发糖代谢紊乱的发生率相关性不明显。Objective To investigate the related factors analysis of hepatitis B liver cirrhosis with secondary glucose metabolism disorders. Methods 184 patients with hepatitis B liver cirrhosis were selected as the research ob- ject and were given 75g oral glucose tolerance test（OGTF） ,then they were divided into three groups[ normal glucose tolerance（NGT） group,impaired glucose tolerance and impaired fasting glucose regulation impairment（IGR） group, diabetic （ DM ） group ] according the results. The general information, laboratory examination and viral load of three groups were compared. Results （ 1 ） The difference of age, waist size, weight, body mass index data and hepatitis B virus load in IGR group and DM group compared with NGT group were statistically significant difference （ all P 〈 0.05 ）, IGR compared with DM group, all index comparative dift^rences were not significant （ all P 〉 0.05 ）. （ 2 ） As the aggravating of glucose metabolism disorder, the positive rate of HBsAg, HBeAg and former S1 antigen of NGT group, IGR group and DM group were gradually raised （ all P 〈 0.05 ）. Conclusion The body mass index and hepati- tis B virus load are relatively independent risk factors of secondary glucose metabolism disorders in patients with hepatitis B liver cirrhosis, and which are positive correlation with it. However, gender, age, blood lipids are not obvious cor- relation with secondary glucose metabolism disorders.

关 键 词：肝炎乙型 肝硬化 糖代谢紊乱 危险因素 

分 类 号：R512.62[医药卫生—内科学]