高容量连续性血液净化在多器官功能障碍综合征患者治疗中的应用  

Application of high volume continuous blood purification in the treatment of multiple organ dysfunction syndrome

作　　者：张淇钏[1] 方喜斌[1] 李智业[1] 陈伟宏[1] 倪晓彬[1] 陈素芝[1] 罗杨[1] 陈纪平[1] 

机构地区：[1]汕头市中心医院重症医学科,广东省汕头515031

出　　处：《中国基层医药》2012年第17期2598-2599,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨高容量与常规容量连续性血液净化（CBP）治疗多器官功能障碍综合征（MODS）的疗效。方法选择MODS患者38例，随机分为高容量CBP组（治疗组）18例、常规容量CBP组（对照组）20例，观察并比较两组治疗后24、48h平均动脉压（MAP）、多巴胺剂量、PaO2／FiO2、APACHEⅡ评分、血乳酸、1CU住院时间、ICU病死率。结果治疗后24、48h，治疗组MAP、PaO2／FiO2升高，多巴胺剂量、APACHEⅡ评分、血乳酸减少，与对照组比较差异均有统计学意义（均P〈0．05）；与对照组比较，治疗组ICU住院时间缩短（8．54±4．15）d与（11．82±5．76）d]、ICU病死率明显降低（22．5％与35．0％）（均P〈0．05）。结论高容量连续性血液净化较常规容量连续性血液净化治疗MODS可降低病死率。Objective To compare the effect of high volume continuous blood purification（CBP） with rou- tine CBP on multiple organ dysfunction syndrome（MODS）. Methods 38 patients with MODS were randomly divided into high volume CBP group（ treatment group, 18 eases） and routine CBP group （control group,20 cases）. And they were respectively detected on mean arterial pressure（MAP） , dosage of Dopamine, PaOJFiO2, APACHE II score,lactic acid,length of stay and mortality in ICU post-treatment 24h and 48h. Results Compared with control group,MAP and PaOJFiO2 on treatment group were more higher （ P 〈 O. 05 ） , while dosage of Dopamine, APACHE U score, lactic acid were significantly shorter than these of treatment group （ P 〈 O. 05 ）, and length of stay and mortality in ICU were signifi- cantly lower than those of treatmen group E （ 8.54 _＋ 4.15 ） d vs （ 11.82 _＋ 5.76 ） d, P 〈 0.05 ;22.2% vs 35.0%, P 〈 0.05 ]. Conclusion High volume CBP could reduce the mortality in ICU compared with control group routine CBP.

关 键 词：血液透析滤过 多器官功能衰竭 

分 类 号：R459.7[医药卫生—急诊医学]