雷公藤多苷片联合黄葵胶囊治疗糖尿病肾病疗效观察  

Observation of the effect of tripterygium combined with huangkui capsule in the treatment of diabetic nephropathy

作　　者：李军辉[1] 

机构地区：[1]商丘市第一人民医院肾内科,河南省商丘476100

出　　处：《中国基层医药》2012年第18期2731-2732,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察雷公藤多苷片联合黄葵胶囊治疗糖尿病肾病的疗效及安全性。方法128例糖尿病。肾病患者随机分为两组，观察组64例采用雷公藤多苷片联合黄葵胶囊治疗；对照组64例单采用黄葵胶囊治疗，比较观察治疗前后两组的临床疗效、尿蛋白水平的变化。结果观察组总有效率为82．8％，高于对照组的65．6％（X2=4．940，P〈O．05）。两组治疗后24h尿微量白蛋白和仪，微球蛋白水平均较治疗前明显下降（t=4．131、3．912、7．253、6．517，均P〈0．05），观察组较对照组下降更明显（t=5．114、4．526，均P〈0．05）。两组均未发生严重不良反应。结论雷公藤多苷片联合黄葵胶囊治疗糖尿病肾病，能够明显提高临床疗效，降低尿蛋白水平，不良反应少。Objective To observe the effect and safety of tripterygium combined with huangkui capsule in the treatment of diabetic nephropathy. Methods 128 diabetic nephropathy patients were classified into two groups, observation group of 64 cases were treated with tripterygium combined with huangkui capsule and control group of 64 cases were treated with buangkui capsule. The clinical effect, urinary protein between the two groups were compared. Results The total effective rate in observation group（82.8% ） was significantly higher than that in control group （65.6%） （X2= 4. 940, P 〈 0.05 ）. After treatment, the levels of 24h urinary microalbumin and oq-microglobulin were significantly decreased in both groups （ t = 4. 131,3.912,7. 253,6.517, all P 〈 0.05 ）. Moreover, the levels of 24h urinary microalbumin and cq-microglobulin in observation group were significantly lower than those in control group（ t = 5.114,4. 526, all P 〈 0.05 ）. Conclusion Tripterygium combined with huangkui capsule in the treatment of diabetic nephropathy could enhance the clinical effects, degrade urinary protein lelves, and had less adverse effect.

关 键 词：糖尿病肾病 雷公藤多苷片 黄葵胶囊 

分 类 号：R277.5[医药卫生—中医学]