消瘤胶囊对大鼠移植肝脏肿瘤的治疗效果研究  

The Study on Treatment of Rat Liver Tumor with XIAOLIU Capsule

作　　者：方志军[1] 姚楠[1] 张健[1] 黄德健[1] 孔铭[1] 孙胜禄[1] 秦慧昊 荆梅[1] 徐荷芬[1] 

机构地区：[1]江苏省中医药研究院,江苏南京210028

出　　处：《药物生物技术》2012年第4期317-320,共4页Pharmaceutical Biotechnology

基　　金：江苏省中医药局项目(No.LZ09064)

摘　　要：采用磁共振影像技术整体评价消瘤胶囊对大鼠Walker-256移植性肝脏肿瘤模型的治疗效果。40只SD大鼠左肝包膜下制成Walker-256移植性肝脏肿瘤模型,待肿瘤长至10 mm×10 mm大小时设为基线,并采用1.5 T磁共振仪行横断面T1WI、T2WI、DWI、CE-T1WI检查;消瘤胶囊治疗后1,2,3,4 w采用以上序列再次进行MRI检查。MRI图像显示,除了肿瘤体积,治疗前后各组肿瘤MRI特征相似,在T1WI图像上呈略低信号,T2WI呈高信号,DWI呈亮高信号,CE-T1WI中央区域低信号,外周高信号。消瘤胶囊治疗后肿瘤体积增长明显小于对照组(P<0.01),坏死面积比率无明显变化(P>0.05)。结果表明,消瘤胶囊持续治疗可以明显抑制肿瘤生长,延长肿瘤大鼠生存期。The study was to evaluate the treatment of Walker-256 rat liver tumor with XIAOLIU Capsule. Transplantation hepatic tumor models were established by inserting pieces of solid tumor into the left liver lobes in 40 SD rats. All rats underwent a baseline MRI examination when the turmors reached 10 mm × 10 mm in diameter. Using a 1.5T MR set ,pre-and post-contrast Tl-weighted imaging（ T1WI）, T2-weighted imaging （ T2WI ） and diffusion-weighted imaging （DWI） were acquired at basehne, 1 week, 2 week, 3 week and 4 week after the administration of XIAOLIU Capsule. The tumors showed similar MRI characteristics except the tumor size. The tumors produced hypointensness on T1WI,hyperintensness on T2WI and strongly hyperintensness on DWI. On CE-T1WI, tumors were hypointensness in the central region relative to peripheral enhanced tumor. The tumors in XIAOLIU capsule-treated group showed a slower growth （P 〈 0.01 ） and no significant changes in tumor necrosis ratio （P 〉 0.05 ） compared with the control group. XIAOLIU Capsule can significantly inhibit the tumor growth and prolong the survival in tumor-bearing rats.

关 键 词：Walker-256肝脏肿瘤模型 磁共振成像 消瘤胶囊 

分 类 号：R965[医药卫生—药理学]