新型甲型H1N1流感症状因子分析  

The Factor Analysis of Symptoms of Influenza A(H1N1)

作　　者：陈雄飞[1] 李铁钢[1] 柳洋[1] 王玉林[1] 陈希[1] 刘建华[1] 李美霞[1] 王鸣[1] 

机构地区：[1]广州市疾病预防控制中心,510440

出　　处：《中国卫生统计》2012年第4期497-499,503,共4页Chinese Journal of Health Statistics

摘　　要：目的探讨因子分析在新型甲型H1N1流感临床症状研究中的应用,为新型甲型H1N1流感基础研究及其防控提供参考。方法利用一次封闭环境下新型甲型H1N1流感暴发数据,使用探索性因子分析探讨新型甲型H1N1流感症状的因子,根据因子的组合,结合专业知识定义因子的临床类型;用证实性因子分析验证因子假设,计算因子负荷,计算每个病例的各因子预测值,分析新型甲型H1N1流感症状的特点。结果探索性因子分析发现,新型甲型H1N1病例的临床症状可以分为消化道症状、卡他症状、下呼吸道症状、全身症状与上呼吸道症状。证实性因子分析发现,2.29%、32.09%、2.87%、7.16%与37.54%的病例分别具有典型的上述对应症状,2.29%、33.52%、4.01%、18.05%与37.54%的病例的主要临床症状类型分别对映前述症状。42.12%的病例不具有任何一种典型临床症状特征,38.68%的病例具有1种,14.33%的病例具有2种,4.87%的病例具有3种。4.58%的病例仅有发热症状。结论新型甲型H1N1流感的症状以呼吸系统症状为主,且以上呼吸道与卡他症状为主。因子分析能较好地应用于新型甲型H1N1流感临床症状特征研究,为临床症状的综合分析提供了新的思路。Objective To explore the using of factor analysis methods in the study of clinical symptoms of Influenza A （H1N1） ,provide reference for the basic research and the disease prevention and control in fu- ture1. Methods Data of clinical symptoms from a Pandemic Influenza A （H1N1） outbreak in a closed environment was analyzed with exploratory factor analysis to get the factor structure of clinical symptoms. Factor struc- ture was verified by confirmatory factor analysis. According to the factor load from confirmatory factor analysis, factors predictive value of every case of each factor can be calculated. According to the predictive value, the main type of clinical symptoms and the typical type of clinical symptoms was de- termined. The characteristics of clinical symptoms can be described by de- scriptive statistical analysis of main type of clinical symptoms and the typi-cal type of clinical symptoms. Results Influenza A （ H1 N1 ） clinical symptoms can be divided into 5 types, namely, gastrointestinal symptoms, catarrhal symptoms, lower respiratory tract symptoms, systemic symptoms and upper respiratory tract symptoms, the typical incidence of which were 2.29% ,32.09% ,2.87% ,7. 16% and 37.54% ,and the main incidence of which were 2.29% ,33.52% ,4. 01% ,18.05% and 37.54%. 42. 12% of the cases can not be classified to any type of typical clinical symptoms. 38.68% of cases with 1 kinds of typical type of clinical symptoms. 14. 33% of cases with 2 kinds of which,4. 87% of the cases with 3 kinds of which, and 4.58 % of cases have only fever. Conclusion The main symptoms of Influenza A （H1N1 ）are respiratory symptoms,especially the up- per respiratory tract symptoms and catarrhal symptoms. Factor analysis is ap- propriate to the study on the character of clinical symptoms of Influenza A （H1N1） ,which can provides a useful reference tips for researchs and practices.

关 键 词：H1N1 流感 症状 因子分析 

分 类 号：R511.7[医药卫生—内科学]