巴戟天寡糖抗抑郁作用的研究进展  

Research advance of morinda officinalis oligosaccharides in treatment of depression

作　　者：邹连勇[1] 张鸿燕[1] 

机构地区：[1]北京大学精神卫生研究所,北京100191

出　　处：《中国新药杂志》2012年第16期1889-1891,1945,共4页Chinese Journal of New Drugs

摘　　要：中药巴戟天化学成分及药理作用复杂。近年来采用现代药理学方法研究巴戟天的药理作用,发现巴戟天提取物在多种抑郁动物模型中具有抗抑郁效果,其主要成分为一组菊淀粉型寡糖同系物。另外,巴戟天寡糖还能够保护神经细胞免受皮质酮的损伤。已有多项临床试验证实巴戟天寡糖胶囊能够治疗轻中度抑郁症,疗效与氟西汀相当,且不良反应较轻。本研究综述目前巴戟天的毒理学及抗抑郁研究进展。Traditional Chinese medicine Morinda officinalis How has complicated chemical constituents and pharmacological effects. In the recent studies on the pharmacological effects of morinda officinalis how by modern pharmacological methods, it was found that its extracts had antidepressant activities in several kinds of animal de- pression models, and the main ingredients were considered as bajitian oligosaccharide. In addition, bajitian oligo- saccharide also could protect the nerve cells from the damage of corticosterone. Confirmed by a number of clinical trials, morinda officinalis oligose capsules have similar effectiveness to fluoxetine in depressive disorder with mild adverse reactions. This article reviewed the progress of the studies on the antidepressant effects and toxicology of morinda officinalis how.

关 键 词：巴戟天 抑郁模型 抗抑郁药 

分 类 号：R971.43[医药卫生—药品]