桃胶多糖降糖机制研究  

Laboratory study on Hypoglycemic Mechanism of Polysaccharide Isolated from Peach Resin

作　　者：王飞[1] 丁婷[1] 谷豪[1] 夏毅伟[1] 韦莉萍[1] 

机构地区：[1]南方医科大学中医药学院,广东广州510515

出　　处：《中医药导报》2012年第8期85-88,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:研究桃胶多糖降低糖尿病大鼠血糖的可能机制。方法:采用水提、梯度醇沉的方法提取3种桃胶多糖,小剂量四氧嘧啶+高糖饲料复制糖尿病模型,桃胶多糖按4 g(/kg.d)晚上灌胃,阿卡波糖作为对照2周后,测定空腹血糖、胰岛素(Ins)、C肽、餐后2 h血糖;分别予淀粉、蔗糖、麦芽糖混合桃胶多糖灌胃后测定0、10、30、60、90、120 min血糖水平。结果:桃胶多糖不能被消化酶分解;与模型组相比,3种桃胶多糖均能降低糖尿病大鼠空腹及餐后血糖水平(P<0.05),Ins及C肽差异无统计学意义(P>0.05);3种分子量桃胶多糖降糖效果差异无统计学意义(P>0.05);与对照组相比桃胶多糖能延缓餐后血糖升高水平。结论:桃胶多糖降糖机制可能与抑制消化酶活性,延缓葡萄糖吸收相关。Objective： To study the hypoglycemic mechanism of polysaccharide isolated from peach resin （PPR） in diabetes mellitus rats. Methods： Three kinds of polysaccharides with different molecular weight were isolated by water extraction and gradient ethanol precipitation; Sprague-Dawley diabetes mellitus rats were induced by high sugar feeding plus several intraperi- toneal injection of low-dose alloxan. Rats with PPR treatment were given 4 g/（kg＇d）, acarbose as control group. After the in- tragastric administration for two weeks, assay the levels of fasting blood glucose, postprandial blood glucose, insulin, C peptide; Assay the levels of blood glucose at the time of 0,10,30,60,120 minute after given starch, sucrose, maltose mixed PPR sepa- rately. Results： PPR can＇t be decompose by digestive enzymes; Compared with model group, three kinds of PPR can reduce diabetic rats fasting blood sugar and postprandial blood sugar level （P〈O.05）; There were no significantly difference on Ins and C-peptide （P〉0.05）; There were no significantly difference hypoglycemic effect among three kinds of PPR and acarbose groups （P〉0.05）; PPR can inhibit the rise of postprandial blood glucose level. Conclusion： The hypoglycemic mechanism of PPR may relate with inhibit the activity of digestive enzymes and delay the glucose absorption.

关 键 词：桃胶多糖 糖尿病 降糖机制 酶抑制剂 

分 类 号：R284[医药卫生—中药学]