奥美拉唑联合莫沙比利治疗反流性食管炎临床疗效观察  

Clinical efficacy observation of omeprazole combined with mosapride for reflux esophagitis

作　　者：贾红云[1] 

机构地区：[1]河南省周口市中心医院消化内科,河南周口466000

出　　处：《中国当代医药》2012年第23期102-103,共2页China Modern Medicine

摘　　要：目的观察奥美拉唑联合莫沙比利治疗反流性食管炎的疗效。方法将86例反流性食管炎患者随机分为对照组和观察组各43例,对照组空腹给予奥美拉唑治疗,观察组在对照组基础上加用莫沙比利,观察两组治疗8周后的临床疗效及药物不良反应等。结果治疗8周后症状缓解情况为对照组总有效30例(69.77%),观察组总有效40例(93.02%),两组差异有统计学意义(P<0.05);内镜下食管黏膜检查,对照组总有效27例(62.79%),观察组总有效38例(88.37%),两组差异有统计学意义(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论奥美拉唑联合莫沙比利治疗反流性食管炎可明显改善患者的症状,疗效优于单用奥美拉唑,且不良反应少,值得临床推广应用。Objective To observe the effect of omeprazole combined with mosapride for reflux esophagitis. Methods Eighty-six patients of reflux esophagitis were randomly divided into control group and observation group, 43 cases in each group, control group was given omeprazole, observation group was given mosapride on the basis of control group, after treat- ment of 8 weeks, the clinical efficacy and adverse drug reactions in the two groups were observed. Results After treatment of 8 weeks, the rates of efficacy in patients of control group and observation group were 30 cases （69.77%） and 40 cases （93.02%）, there was significant difference between the two groups （P 〈 0.05）; Endoscopic examination of esophageal mu- cosal erosion, the percentage of control group and observation group were 27 cases （62.79%） and 38 cases （88.37%）, there was significant difference between the two groups （P 〈 0.05）; there was no significant difference of adverse reaction be- tween two groups （P 〉 0.05）. Conclusion The efficacy of omeprazole eonbined with mosapride in treatment of reflux esophagitis is better than that of omeprazole single, and has little adverse reaction, it is worth popularizing in clinical.

关 键 词：反流性食管炎 奥美拉唑 莫沙比利 临床疗效观察 

分 类 号：R975[医药卫生—药品]