预防移植肝脏再灌注损伤的实验研究  

Study on the Prophylactic Effects of Anisodamine on Ischemia-reperfusion Injury of Grafted Liver

作　　者：马凯[1] 李延钧[1] 卜献民[1] 戴显伟[1] 王亮[1] 

机构地区：[1]中国医科大学第二临床学院外科,沈阳110003

出　　处：《中国医科大学学报》2000年第4期262-263,共2页Journal of China Medical University

基　　金：辽宁省自然科学基金!资助项目 96 2 2 80

摘　　要：目的 :研究在低温保存期间山莨菪碱对移植肝脏的保护作用。方法 :动态观察肝脏缺血—再灌流期间的氧自由基变化。结果 :用山莨菪碱可减少再灌流后脂质过氧化物的增加 ,超氧化物歧化酶和谷胱甘肽过氧化物酶的下降。结论 :在再灌流前应用山莨菪碱能减少再灌流后氧自由基的产生 ,可减轻缺血—再灌流对移植肝脏的损伤。Objective: To study the protective effect of anisodamine on donor liver in low temperature.Methods: Changes of free radical and enzymes in donor liver during ischemia-reperfusion stage were observed dynamically. Results:The increase of LPO and decrease of SOD and GSH-Px after ischemia-reperfusion were lessened by anisodamine. Conclusion:Pre-reperfusive prophylactic application of anisodamine can decrease the production of oxygen-derived free radical,therefore reduce the hepatic injury during ischemia-reperfusion stage.

关 键 词：肝移植 氧自由基 山莨菪碱 再灌注损伤 预防 

分 类 号：R657.3[医药卫生—外科学]