葛根素治疗糖尿病视网膜病变的疗效观察  

Observation on Efficacy of Puerarin in Treating Diabetic Retinopathy

作　　者：任平[1] 胡惠君[1] 张瑞[1] 

机构地区：[1]辽宁中医学院附属医院,沈阳110032

出　　处：《中国中西医结合杂志》2000年第8期574-576,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的 :运用活血化瘀、通经活络原理 ,观察葛根素对糖尿病视网膜病变患者视网膜中央动静脉血流参数及血液流变学影响。方法 :30例糖尿病视网膜病变 ,随机分为治疗组 (15例 )和对照组 (15例 )。治疗组在常规降血糖药物治疗的同时 ,加用葛根素 4 0 0mg ,每日 1次 ,静脉滴注 ;对照组加用弥克保 50 0 μg ,每日 1次 ,肌肉注射。均 3周为 1个疗程 ,连续用药 2个疗程 ,观察用药前后血液流变学各项指标及视网膜中央动静脉血流参数。结果 :治疗组治疗前后比较 ,红细胞聚集指数、全血比粘度、血浆比粘度、纤维蛋白原及血沉比治疗前均有明显改善 (P <0 0 5,P <0 0 1) ;两组治疗后比较有显著性差异 (P <0 0 5)。治疗组治疗前后视网膜中央动脉的收缩峰值血液速度 (PSV)、舒张末期血流最大速度 (EDV)、加速度 (A)、视网膜中央静脉回流速度 (CRV)均有改善 (P <0 0 5) ,裸眼视力均有不同程度的提高。结论 :葛根素具有降低血液粘稠度 ,改善微循环的作用 ,对糖尿病视网膜病变有肯定的治疗作用。Using promoting blood circulation to remove stasis principle to observe arteria and vena centralis retinae blood flow indexes, and hemorrheology of diabetic retinopathy patients with Puerarin. Methods: Thirty patients with diabetic retinopathy were randomly divided into the treated group (n=15) and the control group (n=15). The treated group were given Puerarin 400mg per day intravenously dripping. The control group were given Mikebao 500μg intramuscularly, once per day. Both groups were taken 3 consecutive weeks as one treatment course. Two courses later, observing hemorrheologic parameters, arteria and vena centralis retinae blood flow indexes. Results: Comparing before and after treatment the RBC aggregation index, the whole blood viscosity rate, plasma viscosity rate, fibrinogen and erythrocyte sedimentation rate, have improved obviously (P<0 05,P<0 01). Comparing with the control group, there was significant difference (P<0 05,P<0 01). The difference of treated group between before and after treatment, the peak systolic velocity (PSV) of arteria centralis retinae, their end diastolic volume (EDV), the acceleration (A), the central retinal vein reflux velocity (CRV) have improved respectively. Naked eye visions were also improved, comparing with the control group, the difference was significant (P<0 01). Conclusion: Puerarin can reduce blood viscosity, improve microcirculation, and plays a positive therapeutic role in diabetic retinopathy.

关 键 词：葛根素 糖尿病视网膜病变 中医药疗法 疗效 

分 类 号：R259[医药卫生—中西医结合]