毫米波对大鼠血清中活性氧、一氧化氮及其相关酶的影响  

Effects of low-intensity millimeter wave radiation on active oxygen,nitric oxide and their related enzymes in serum of rats

作　　者：刘朝晖[1] 王小娟[2] 陈景藻 王俊卿[1] 莫简[4] 孙淑芬[4] 陶秦渝[5] 

机构地区：[1]第四军医大学唐都医院康复科,西安710038 [2]西京医院神经内科 [3]西京医院理疗学与康复医学教研室 [4]第四军医大学化学教研室 [5]第四军医大学唐都医院中心实验室,西安710038

出　　处：《中华物理医学与康复杂志》2000年第4期215-216,共2页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：国家自然科学基金资助项目!(39670 697)

摘　　要：目的　观察低功率毫米波经皮肤辐射能否引起大鼠血中活性氧、一氧化氮及其相关酶的改变 ,以探索其作用机制。方法　应用波长 5 .6mm、功率密度 10mW /cm2 极高频电磁波辐射大鼠腰背部皮肤 ,每天 1h ,连续 7d ,采集心血 4ml ,测定其血清中总超氧化物歧化酶 (T SOD)、氮氧合酶 (NOS)活性以及脂质过氧化物丙二醛 (MDA)和一氧化氮 (NO)含量。结果　辐射组T SOD、NOS活性下降 ,NO含量减少 ,MDA含量无明显改变。结论　 5 .6mm、10mW /cm2 电磁辐射可影响大鼠血中某些酶的活性 ,但未造成血细胞的明显损害。Objective To examine the changes of active oxygen,nitric oxide and their related enzymes in rat serum by millimeter wave and their mechanism. Methods Use 5.6 mm,10 mW/cm 2 extremely high frequency electromagnetic wave (millimeter wave) to irradiate the skin on waist and back of rats once daily (1 h) for 7 d, and then to collect the blood from rat heart each for 4 ml and to investigate the activities of total superoxide dismutase (T SOD) and nitric oxide synthase (NOS) as well as the contents of lipid peroxide (MDA) and nitric oxide (NO). Results For the group of radiation, the activities of T SOD and NOS decreased, meanwhile the contents of NO declined,but no significant difference was observed in MDA. Conclusion 5.6 mm, 10 mW/cm 2 electromagnetic irradiation can attenuate the activity of some enzymes in rat serum,but not cause significant impairment of their blood cells.

关 键 词：毫米波 超氧化物歧化酶 氮氧合酶 LPO 一氧化氮 

分 类 号：R454.1[医药卫生—治疗学]