脑外伤患者血清兴奋性氨基酸水平与功能性恢复的分析  

Excitatory amino acids and their relation to rehabilitation results of brain injury

作　　者：汪平[1] 郭正成 

机构地区：[1]苏州市第四人民医院康复科,215001 [2]同济医院康复科

出　　处：《中华物理医学与康复杂志》2000年第4期231-233,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的　探讨脑外伤患者血清氨基酸水平与功能恢复的相关性。方法　采用高效液相色谱法(HPLC)检测了 3 0例急性脑外伤患者外伤后 2 4h内和 6d后的血清中谷氨酸 (GLU)的水平 ,并在 2 4h内采用格拉斯哥昏迷量表计分 (GCS)及 2 0d后功能独立性 (FIM )的评定值进行相关性研究。结果　显示血清GLU( 2 4h)的水平和GCS、FIM得分呈良好的负相关 ,将 2 4h测量的血清GLU浓度与 6d血清GLU浓度值比较 ,分为持续增高组与降低组 ,两组 2 0d后的FIM平均得分有显著性差异 ( P <0 .0 1) ,GLU血清浓度持续增高组的FIM得分远远低于GLU浓度降低组。结论　脑外伤患者血清GLU浓度可影响脑组织的损伤程度 ,并参与继发性的脑损伤 ,影响患者功能的恢复。Objective To study relation of levels of excitatory amino acids and rehabilitation results of the patients with brain injury. Methods High performance liquid chromatography was used to determine the glutamate concentration in the plasma of patients in 24 h and after 6 d with brain injury, and relative analysis with Glasgow Coma Scale (GCS) and Function Independent Measure (FIM) was made. Results The studies showed that the concentration of plasmatic glutamate was closely related to GCS and FIM (negative correlation with GCS and FIM,r 1=- 0.6566 ,P 1< 0.001 ; r 2=- 0.4839 ,P 2< 0.001 ).Conclusion The results suggest that excitatory amino acids may reflect the degree of patients with secondary cerebral damage and be as biochemical marks for evaluating the brain injury.

关 键 词：谷氨酸 脑外伤 兴奋性氨基酸 HPLC GCS FIM 

分 类 号：R651.1[医药卫生—外科学]