消瘀片及其组分对粥样硬化兔血清LDL电泳迁移率和血管壁中ET-1 mRNA及iNOS mRNA表达影响的比较  

Comparison of the Effects of Xianyu Tablet and Its Component on Electrophoretic Mobility of Serum LDL and Expression of ET-1 mRNA and iNOS mRNA of Vessel Wall in Atherosclerotic Rabbits

作　　者：谢梅林[1] 陆群[1] 朱路佳[1] 顾振纶[1] 

机构地区：[1]苏州中药研究所,215007

出　　处：《中药材》2000年第8期474-476,共3页Journal of Chinese Medicinal Materials

摘　　要：消瘀片由丹参提取物和山楂提取物组成,为验证其组方的合理性,本文比较消瘀片及其组分对粥样硬化兔血清 LDL电泳迁移速率和血管壁组织中 ET-1 mRNA及 iNOS mRNA表达的影响。结果表明,消瘀片对抑制血管壁中 iNOS mRNA表达作用与其组分丹参提取物和山楂提取物相似,但对减慢血清LDL电泳迁移速率和抑制血管壁中ET-1 mRNA表达的作用明显增强,提示两者合用后对防治动脉粥样硬化可产生明显的协同效应。Xiaoyu tablet,a compound preparation of Chinese herbal medicines,consists of Radix Salviae Miltiorrhizae(SM) and Fructus Crataegi(FC)extracts.To determine whether the proved recipe was reasonable, the effects of Xiaoyu tablet and its component on electrophoretic mobility of serum LDL and expression of ET-1 mRNA and iNOS mRNA of vessel wall in atherosclerotic rabbits were observed. The results indicated that inhibition of expression iNOS mRNA in vessel wall by Xiaoyu tablet was the same as its single extract of SM or FC,but Xiaoyu talbet was superior to SM or FC extract in reduction of electrophoretic mobility of serum LDL and inhibition of ET-1 mRNA expression in vessel wall.These results suggested that there was obvious synergism on prevention and treatment of atherosclerosis when both of the Chinese herbal medicines were simultaneously used.

关 键 词：消瘀片 丹参 山楂 LDL ET-1 NOS 动脉粥样硬化 

分 类 号：R285.5[医药卫生—中药学] R286.26[医药卫生—中医学]