黄芪对肠缺血-再灌注损伤过程中肺表面活性物质及LPO含量的影响  

Effect of Astragalus membranaceus on pulmonary surfactant and lipid-peroxides during intestines ischemia-reperfusion injury

作　　者：崔和勤[1] 李占军[1] 杨秋[1] 张硕森[2] 李宏杰[2] 景有伶[2] 张连元[2] 王献华[3] 孙瑞军[3] 

机构地区：[1]华北煤炭医学院生物化学教研室,河北唐山063000 [2]华北煤炭医学院病理生理教研室,河北唐山063000 [3]华北煤炭医学院病理教研室,河北唐山063000

出　　处：《中国新药与临床杂志》2000年第4期270-272,共3页Chinese Journal of New Drugs and Clinical Remedies

基　　金：煤炭科学基金项目资助!(96141600451)

摘　　要：目的 :探讨肠缺血 再灌注损伤时 ,肺表面活性物质及脂质过氧化物 (LPO)含量的改变及其意义 ,以及黄芪在缺血 再灌注过程中对肺损伤的保护作用。方法 :复制家兔肠损伤模型 ,测定血浆和肺组织LPO及肺表面活性物质含量变化 ,同时计算肺系数及进行肺病理学检查 ,并观察黄芪对LPO及肺表面活性物质含量的影响。结果 :静脉给予黄芪注射液可提高肺表面活性物质含量 ,减少LPO的生成 ,对缺血 再灌注引起的肺组织损伤有明显的保护作用。结论 :肺表面活性物质下降可能与LPO上升有关 ,黄芪通过其稳膜作用能减轻或在一定程度上防止缺血AIM: To study the change of pulmonary surfactant (PS), lipid peroxide (LPO), and the protective effects of astragalius membranaceus on the ischemiareperfusion (I/R) injury. METHODS: Models of rabbits I/R injury were made. The effects of astragalius membranaceus on PS, LPO in blood plasma and lung tissue were tested. RESULTS: Astragalus membranaceus by intravenous route could decrease the LPO and prevent reduction of the PS during the I/R injury. CONCLUSION: It is suggested that lung were injured in I/R by free radical. The astragalus membranaceus possesses therapeutic and preventive effects through anitlipid peroxidation.

关 键 词：黄芪 肺表面活性剂 再灌注损伤 肠缺血 LPO 

分 类 号：R259.74[医药卫生—中西医结合] R286.2[医药卫生—中医内科学]